Overview
| Uniprot ID | F1RK74 |
|---|
| Protein Name | Tricarboxylate transport protein, mitochondrial |
|---|
| Gene Name | SLC25A1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 296 |
ILRNEGLKAFYKGTI |
| 300 |
EGLKAFYKGTIPRLG |
| 329 |
EVVKLLNKVWKTD** |
Function
Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes
Protein Sequence
10
MADPRALAAA
20
APAPGKAKLT
30
HPGKAILAGG
40
LAGGIEICIT
50
FPTEYVKTQL
60
QLDERSHPPR
70
YRGIGDCVRQ
80
TVRSHGVLGL
90
YRGLSSLLYG
100
SIPKAAVRFG
110
TFEFLSNHMR
120
DAQGRLDSTR
130
GLLCGLGAGV
140
AEAVVVVCPM
150
ETIKVKFIHD
160
QTSSNPKYRG
170
FFHGVREIVR
180
EQGLKGTYQG
190
LTATVLKQGS
200
NQAIRFFVMT
210
ALRNWYRGDN
220
PNKPMNPLIT
230
GVFGAIAGAA
240
SVFGNTPLDV
250
IKTRMQVWAW
260
PGRGRGQERG
270
WLLSLIVSGV
280
LQGLEAHKYR
290
NTWDCGLQIL
300
RNEGLKAFYK
310
GTIPRLGRVC
320
LDVAIVFIIY
330
DEVVKLLNKV
WKTD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.