Search Results
Overview
| Uniprot ID | F1RKF3 |
|---|---|
| Protein Name | Leucine-rich repeat and WD repeat-containing protein 1 |
| Gene Name | LRWD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 477 | VRLDQPQKRRVCEAE |
Function
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability
Protein Sequence
10
MGPLSVRLLI
20
QRGRPKSDRL
30
GKIRSLDLSG
40
LKLLSEHLDP
50
KLLSRLKQLQ
60
ELDLSNNQLE
70
TLPANLGLSH
80
LRILRCANNQ
90
LGDVTALCQF
100
PQLEELSLEG
110
NPFLTVSDNL
120
KVSFLLPKLR
130
KVNGKDASST
140
CSQVENLNRE
150
LTSRVTAHWE
160
KFMAALSPEE
170
ETEKAQADFV
180
RSAVRDVRYG
190
PESLSDFTQW
200
RVRMISEELV
210
ASGGTHVHEA
220
DIPERPPKTR
230
ATREPRARPV
240
ALKRPSDIPL
250
SLSPSKRELT
260
SPLAQAEGSP
270
VGSDGSQLEP
280
LHFLQCHSKN
290
NSPRDLETQL
300
WACAFEPAWD
310
EGHAGATSQT
320
VATCGGEAVC
330
VIDCQTGIVL
340
HKYKSPGEEF
350
FSVAWTALTV
360
VTQAGHKKRW
370
SVLAAAGLRG
380
LVRLLHVRAG
390
FCCGVIRAHK
400
KAIATLCFSP
410
THETHLFTAS
420
YDKRIVLWDI
430
GVPNHDYEFQ
440
ASQLLTLDTT
450
SIALRLCPVA
460
SCPDAYLLAG
470
CEGGCCCWDV
480
RLDQPQKRRV
490
CEAEFTFPEG
500
SEASGRRVDG
510
LAFVNEDVVA
520
SKGSGLGTIC
530
LWSWSQTWLG
540
RGSQSTVAVV
550
VLARLQWSPT
560
ELAYFSLSTC
570
PDEGLVLCGD
580
EEGHVWIYDV
590
RHILAQRPPL
600
PVAPQAPTQI
610
LKWPQPQALG
620
QTVTRTMVNM
630
VVANRTFTYL
640
TALTDSNIVA
IWRRARP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005664 | nuclear origin of replication recognition complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0061628 | histone H3K27me3 reader activity |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.