Search Results

Overview

Uniprot IDF1RKM0
Protein NameLamin-B1
Gene NameLMNB1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
102 DTARERAKLQIELGK
109 KLQIELGKFKAEHDQ
111 QIELGKFKAEHDQLL
156 LATALGDKKSLESDL
258 EQHDAQVKLYKEELE
261 DAQVKLYKEELEQTY
312 SQLSNLQKESRACLE
33 RLSRLQEKEELRELN
330 ELEDLLAKERDNSRR
389 EGEEERLKLSPSPSS
474 GGWEMIRKIGDTSVS
483 GDTSVSYKYTSRYVL
49 RLAVYIDKVRSLETE
532 EDVKVILKNSQGEEV

Function

Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively

Protein Sequence

10 MATATPVQSR 20 TGSRAGGPTT 30 PLSPTRLSRL 40 QEKEELRELN 50 DRLAVYIDKV 60 RSLETENSAL 70 QLQVTEREEV 80 RGRELTGLKA 90 LYETELADAR 100 RALDDTARER 110 AKLQIELGKF 120 KAEHDQLLLN 130 YAKKESDLNG 140 AQIKLREYEA 150 ALNSKDAALA 160 TALGDKKSLE 170 SDLEDLKDQI 180 AQLEASLAAA 190 KKQLADETLL 200 KVDLENRCQS 210 LTEDLEFRKN 220 MYEEEINETR 230 RKHETRLVEV 240 DSGRQIEYEY 250 KLAQALHEMR 260 EQHDAQVKLY 270 KEELEQTYHA 280 KLENARLSSE 290 MNTSTVNSAR 300 EELMESRMRI 310 ESLSSQLSNL 320 QKESRACLER 330 IQELEDLLAK 340 ERDNSRRMLS 350 DKEREMAEIR 360 DQMQQQLNDY 370 EQLLDVKLAL 380 DMEISAYRKL 390 LEGEEERLKL 400 SPSPSSRVTV 410 SRASSSRSVR 420 TTRGKRKRVD 430 VEESEASSSV 440 SISHSASATG 450 NVCIEEIDVD 460 GKFIRLKNTS 470 EQDQPMGGWE 480 MIRKIGDTSV 490 SYKYTSRYVL 500 KAGQTVTIWA 510 ANAGVTASPP 520 TDLIWKNQNS 530 WGTGEDVKVI 540 LKNSQGEEVA 550 QRSTVFKTTI 560 PEEEEEEEEA 570 AEVAVEEELF 580 HQQGAPRGSN RSCAIM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005638 lamin filament
Cellular Component GO:0005637 nuclear inner membrane
Cellular Component GO:0005652 nuclear lamina
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0043274 phospholipase binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0160123 structural constituent of nuclear lamina
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0006998 nuclear envelope organization
Biological Process GO:0007097 nuclear migration
Biological Process GO:0051664 nuclear pore localization
Biological Process GO:0090435 protein localization to nuclear envelope

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.