Overview
| Uniprot ID | F1RKQ8 |
|---|
| Protein Name | Cleavage and polyadenylation specificity factor subunit 7 |
|---|
| Gene Name | CPSF7 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 397 |
RVLISSLKDCLHGIE |
Function
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates
Protein Sequence
10
MSEGVDLIDI
20
YADEEFNQDP
30
EFNNTDQIDL
40
YDDVLTATSQ
50
PSDDRSSSTE
60
PPPPVRQEPS
70
PKPNNKTPAI
80
LYTYSGLRNR
90
RAAVYVGSFS
100
WWTTDQQLIQ
110
VIRSIGVYDV
120
VELKFAENRA
130
NGQSKGYAEV
140
VVASENSVHK
150
LLELLPGKVL
160
NGEKVDVRPA
170
TRQNLSQFEA
180
QARKRECVRV
190
PRGGIPPRAH
200
SRDSSDSADG
210
RATPSENLVP
220
SSARVDKPPS
230
VLPYFNRPPS
240
ALPLMGLPPP
250
PIPPPPPLSS
260
SFGVPPPPPG
270
IHYQHLMPPP
280
PRLPPHLAVP
290
PPGAIPPALH
300
LNPAFFPPPN
310
ATVGPPPDTY
320
MKASTPYNHH
330
GSRDSGPPPS
340
TVSEAEFEEI
350
MKRNRAISSS
360
AISKAVSGAS
370
AGDYSDAIET
380
LLTAIAVIKQ
390
SRVANDERCR
400
VLISSLKDCL
410
HGIEAKSYSV
420
GASGSSSRKR
430
HRSRERSPSR
440
SRESSRRHRD
450
LLHNEDRHDD
460
YFQERNREHE
470
RHRDRERDRH
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005847 |
mRNA cleavage and polyadenylation specificity factor complex |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0180010 |
co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway |
| Biological Process |
GO:0110104 |
mRNA alternative polyadenylation |
| Biological Process |
GO:0051290 |
protein heterotetramerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.