Overview
| Uniprot ID | F1RKW8 |
|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 11 |
|---|
| Gene Name | PSMD11 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 294 |
KCVAQASKNRSLADF |
| 32 |
DILHSIVKRDIQEND |
| 354 |
EHISSLIKLSKADVE |
| 357 |
SSLIKLSKADVERKL |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity
Protein Sequence
10
MAAAAVVEFQ
20
RAQSLLSTDR
30
EASIDILHSI
40
VKRDIQENDE
50
EAVQVKEQSI
60
LELGSLLAKT
70
GQAAELGGLL
80
KYVRPFLNSI
90
SKAKAARLVR
100
SLLDLFLDME
110
AATGQEVELC
120
LECIEWAKSE
130
KRTFLRQALE
140
ARLVSLYFDT
150
KRYQEALHLG
160
SQLLRELKKM
170
DDKALLVEVQ
180
LLESKTYHAL
190
SNLPKARAAL
200
TSARTTANAI
210
YCPPKLQALD
220
MQSGIIHAAE
230
EKDWKTAYSY
240
FYEAFEGYDS
250
IDSPKAITSL
260
KYMLLCKIML
270
NTPEDVQALV
280
SGKLALRYAG
290
RQTEALKCVA
300
QASKNRSLAD
310
FEKALTDYRA
320
ELRDDPIIST
330
HLAKLYDNLL
340
EQNLIRVIEP
350
FSRVQIEHIS
360
SLIKLSKADV
370
ERKLSQMILD
380
KKFHGILDQG
390
EGVLIIFDEP
400
PVDKTYEAAL
410
ETIQNMSKVV
420
DSLYNKAKKL
T
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008541 |
proteasome regulatory particle, lid subcomplex |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Biological Process |
GO:0043248 |
proteasome assembly |
| Biological Process |
GO:0048863 |
stem cell differentiation |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.