Search Results
Overview
| Uniprot ID | F1RL02 |
|---|---|
| Protein Name | Mitogen-activated protein kinase |
| Gene Name | MAPK1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 270 | LSLPHKNKVPWNRLF |
| 342 | DLPKEKLKELIFEET |
| 92 | KVRVAIKKISPFEHQ |
Function
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity
Protein Sequence
10
MQISLSVSVT
20
LPASVVGRAA
30
AAEHRAQCGG
40
GGGGPAANMA
50
AAAAGAGPEM
60
VRGQVFDVGP
70
RYTNLSYIGE
80
GAYGMVCSAY
90
DNVNKVRVAI
100
KKISPFEHQT
110
YCQRTLREIK
120
ILLRFRHENI
130
IGINDIIRAP
140
TIEQMKDVYI
150
VQDLMETDLY
160
KLLKTQHLSN
170
DHICYFLYQI
180
LRGLKYIHSA
190
NVLHRDLKPS
200
NLLLNTTCDL
210
KGYTKSIDIW
220
SVGCILAEML
230
SNRPIFPGKH
240
YLDQLNHILG
250
ILGSPSQEDL
260
NCIINLKARN
270
YLLSLPHKNK
280
VPWNRLFPNA
290
DSKALDLLDK
300
MLTFNPHKRI
310
EVEQALAHPY
320
LEQYYDPSDE
330
PIAEAPFKFD
340
MELDDLPKEK
350
LKELIFEETA
RFQPGYRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004707 | MAP kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Biological Process | GO:0006915 | apoptotic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.