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Overview

Uniprot IDF1RLQ5
Protein Name-
Gene NamePOGLUT2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
181 KIATEIPKRFGQRQS

Function

Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway

Protein Sequence

10 MFSILLLYCF 20 FLGTVPTLAE 30 TGGERRVSPE 40 KSEIWGPGLK 50 AAVVLPARYF 60 YIQAVDTSGN 70 KFTTSPGDKV 80 FQIKISAPDE 90 QFTRVGVQVL 100 DRKDGSFIVR 110 YRMYASYKNL 120 KVEVKFQGQH 130 VAKSPYILKG 140 PVYHENCDCP 150 LEDAAAWLRE 160 MSCPETIPQI 170 QRDLAQFPSV 180 DPEKIATEIP 190 KRFGQRQSLC 200 HYTLKDNKVY 210 IKTHGEHVGF 220 RIFMDAILLS 230 LTRKVKMPDV 240 EFFVNLGDWP 250 LEKKKSGSHI 260 HPIFSWCGST 270 DSKDIVMPTY 280 DLTDSVLETM 290 GRVSLDMLSV 300 QANTGPPWES 310 KNSTAVWRGR 320 DSRKERLELV 330 KLSRKHPELI 340 DAAFTNFFFF 350 KHDESLYGPI 360 VKHISFFDFF 370 KHKYQINVDG 380 TVAAYRLPYL 390 LVGDSVVLKQ 400 DSIYYEHFYN 410 ELQPWKHYIP 420 VRSNLSDLLE 430 KLKWAKDHDE 440 EAKKIAKTGQ 450 EFARNNLMGD 460 DIFCYYFKLF 470 QEYASLQVSE 480 PQIREGMERV 490 QPQTEDDLFP 500 CACHRKKTKD EL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0012505 endomembrane system
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0046527 glucosyltransferase activity
Molecular Function GO:0035251 UDP-glucosyltransferase activity
Molecular Function GO:0035252 UDP-xylosyltransferase activity
Biological Process GO:0180059 protein O-linked glycosylation via glucose

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.