Search Results
Overview
| Uniprot ID | F1RMF1 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase ZFP91 |
| Gene Name | ZFP91 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 125 | PRLLCTEKVSTSKDP |
| 331 | YQHLLKKKYVCPHPS |
Function
DNA-binding transcription factor. Also acts as an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis
Protein Sequence
10
MPGETEEPRP
20
PEQQDQEGGE
30
AAAAAKAAPE
40
EPQQQPPEEA
50
AVAAPAGTTT
60
SRVLRGGRDR
70
GRAAAAAAAA
80
AAAAVSRRRK
90
AEYPRRRRSS
100
PSARPPDAPG
110
QQSQAAKPPS
120
PAQGKKSPRL
130
LCTEKVSTSK
140
DPKEEKEEDD
150
SALPQEASIA
160
ATRPSRGWRS
170
SSRTSVSRHR
180
DTENTRSSRS
190
KTGSLQLICK
200
SEPNTDQLDY
210
DVAEEHQSPG
220
GISSDEEEEE
230
EEEMLISEEE
240
IPFKDDPRDE
250
TYKPHLERET
260
PKPRRKSGKV
270
KEEKEKKEIK
280
VEVEVEVKEE
290
ENEIREDEEP
300
PRKKKPPIQY
310
VRCEMEGCGT
320
VLAHPRYLQH
330
HIKYQHLLKK
340
KYVCPHPSCG
350
RLFRLQKQLL
360
RHAKHHTDQR
370
DYICEYCARA
380
FKSSHNLAVH
390
RMIHTGEKPL
400
QCEICGFTCR
410
QKASLNWHMK
420
KHDADSFYQF
430
SCNICGKKFE
440
KKDSVVAHKA
450
KSHPEVLIAE
460
ALAANAGALI
470
TSTDILGTNP
480
ESLTQPADGQ
490
GLPLLPEPLG
500
NSTSGECLLL
510
EAEGMSKSYC
SGTDSLHQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0060255 | regulation of macromolecule metabolic process |
| Biological Process | GO:0080090 | regulation of primary metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.