Search Results
Overview
| Uniprot ID | F1RMW4 |
|---|---|
| Protein Name | DNA repair protein XRCC1 |
| Gene Name | XRCC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 252 | ESPKGKRKLDLNQEA |
| 276 | QPSPPALKRPKLPAA |
| 303 | ARGAAPGKPRGEGAK |
Function
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity
Protein Sequence
10
MPEIRLRHVV
20
SCSSQDSTHC
30
AENLLKADTY
40
RKWRAAKAGE
50
KTISVVLQLE
60
KEEQIHSVDI
70
GNDGSAFVEV
80
LVGSSAGGAG
90
EQDYEVLLVT
100
SSFMSPSESR
110
SGSNPNRVRI
120
FGPDKLVRAA
130
AEKRWDRVKI
140
VCSQPYSKDA
150
PYGLSFIRFH
160
SPPDKDEAEA
170
SSQKVTRLGQ
180
FRVKEEDEST
190
SSLRPGALFF
200
SRINRTPPVA
210
ASDPAGPSYA
220
AATLQASSAA
230
SSVSPASKAT
240
GSASRAAGST
250
SKPQESPKGK
260
RKLDLNQEAK
270
KTPSKPSAQP
280
SPPALKRPKL
290
PAAPRTPATA
300
PLPAPARGAA
310
PGKPRGEGAK
320
PRAPRAGPQE
330
LGKILQGVVV
340
VLSGFQNPFR
350
SELRDKALEL
360
GAKYRPDWTP
370
DSTHLICAFA
380
NTPKYSQVLG
390
LGGRIVRKEW
400
VLDCHRMRRR
410
LPSRRYLMAG
420
PDSSSEDEGG
430
SPGGSSGDEA
440
PKPPRQRPQT
450
KARPPQAAGP
460
SLPQRPPAPE
470
ETKPASPRPQ
480
DDTDIEGEQS
490
GQDNGAEDSG
500
DTEDELRRVA
510
EQKEQRQPPG
520
QGENGEDPYA
530
GSTDENTDNE
540
GPPESPDLPV
550
PELPDFFQGK
560
HFFLYGEFPG
570
DERRRLSRYV
580
TAFNGELEDY
590
MSDRVQFVIT
600
AQEWDPSFEE
610
ALMDNPSLVF
620
VRPRWIYSCN
630
EKQKLLPHQL
YGVVPQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0032356 | oxidized DNA binding |
| Molecular Function | GO:0072572 | poly-ADP-D-ribose binding |
| Molecular Function | GO:1990165 | single-strand break-containing DNA binding |
| Biological Process | GO:0006284 | base-excision repair |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:1905765 | negative regulation of protection from non-homologous end joining at telomere |
| Biological Process | GO:1905051 | regulation of base-excision repair |
| Biological Process | GO:0033194 | response to hydroperoxide |
| Biological Process | GO:0000012 | single strand break repair |
| Biological Process | GO:0061819 | telomeric DNA-containing double minutes formation |
| Cellular Component | GO:0070522 | ERCC4-ERCC1 complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0090734 | site of DNA damage |
| Molecular Function | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity |
| Molecular Function | GO:0160002 | ADP-D-ribose modification-dependent protein binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.