Overview
| Uniprot ID | F1RMZ8 |
|---|
| Protein Name | Vacuolar proton pump subunit B |
|---|
| Gene Name | ATP6V1B2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
GTSGIDAKKTSCEFT |
| 109 |
TSGIDAKKTSCEFTG |
Function
Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load
Protein Sequence
10
MALRAMRGIV
20
NGAAPELPVS
30
TSGPMVGSRE
40
QALAVSRNYL
50
SQPRLTYKTV
60
SGVNGPLVIL
70
DHVKFPRYAE
80
IVHLTLPDGT
90
KRSGQVLEVS
100
GSKAVVQVFE
110
GTSGIDAKKT
120
SCEFTGDILR
130
TPVSEDMLGR
140
VFNGSGKPID
150
RGPVVLAEDF
160
LDIMGQPINP
170
QCRIYPEEMI
180
QTGISAIDGM
190
NSIARGQKIP
200
IFSAAGLPHN
210
EIAAQICRQA
220
GLVKKSKDVV
230
DYSEENFAIV
240
FAAMGVNMET
250
ARFFKSDFEE
260
NGSMDNVCLF
270
LNLANDPTIE
280
RIITPRLALT
290
TAEFLAYQCE
300
KHVLVILTDM
310
SSYAEALREV
320
SAAREEVPGR
330
RGFPGYMYTD
340
LATIYERAGR
350
VEGRNGYITH
360
PIPDLTGYIT
370
EGQIYVDRQL
380
HNRQIYPPIN
390
VLPSLSRLMK
400
SAIGEGMTRK
410
DHADVSNQLY
420
ACYAIGKDVQ
430
AMKAVVGEEA
440
LTSDDLLYLE
450
FLQKFERNFI
460
AQGPYENRTV
470
YETLDIGWQL
480
LRIFPKEMLK
490
RIPQSTLSEF
YPRDSAKH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0033180 |
proton-transporting V-type ATPase, V1 domain |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0046034 |
ATP metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.