Overview
| Uniprot ID | F1RNN0 |
|---|
| Protein Name | Vacuolar protein sorting-associated protein 29 |
|---|
| Gene Name | VPS29 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 29 |
RCNSLPAKFKKLLVP |
| 32 |
SLPAKFKKLLVPGKI |
| 51 |
CTGNLCTKESYDYLK |
Function
Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes
Protein Sequence
10
IFSHLDTLKL
20
VLVLGDLHIP
30
HRCNSLPAKF
40
KKLLVPGKIQ
50
HILCTGNLCT
60
KESYDYLKTL
70
AGDVHIVRGD
80
FDENLNYPEQ
90
KVVTVGQFKI
100
GLIHGHQVIP
110
WGDMASLALL
120
QRQFDVDILI
130
SGHTHKFEAF
140
EHENKFYINP
150
GSATGAYNAL
160
ETNIIPSFVL
170
MDIQASTVVT
180
YVYQLIGDDV
190
KVERIEYKKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0030906 |
retromer, cargo-selective complex |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.