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Overview

Uniprot ID	F1RPN9
Protein Name	Malic enzyme
Gene Name	ME2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
132	GHIFRRPKGLFISIS

Function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate

Protein Sequence

10 MMLSRFKIVA 20 TPCTLACRHL 30 HIKEKGKPLM 40 LNPRTNKGMA 50 FTLQERQMLG 60 LQGLLPPKIE 70 TQDIQALRFH 80 RNVKKLNGPL 90 EKYIYIMGIQ 100 ERNEKLFYRI 110 LQDDIETLMP 120 IVYTPTVGLA 130 CSQYGHIFRR 140 PKGLFISISD 150 RGHVRSIVDN 160 WPENHVKAVV 170 VTDGERILGL 180 GDLGVYGMGI 190 PVGKLCLYTA 200 CAGIRPDRCL 210 PVCIDVGTDN 220 PALLKDPFYM 230 GLYQKRDRSQ 240 RYDDLIDEFM 250 KAITDRYGRN 260 ILIQFEDFGN 270 HNAFRFLRKY 280 REKYCTFNDD 290 IQGTAAVALA 300 GLLAAQKVIG 310 KSISEHKILF 320 LGAGEGRKAK 330 IDSHQEPFAH 340 PAPDNIPDNF 350 EDAVNILKPS 360 AIIGVAGAGR 370 LFTHNVIKAM 380 ADINERPIIF 390 ALSNPTAQAE 400 CTAEEAYTLT 410 EGRCLFASGS 420 PFGPVKLSDG 430 QVFTPGQGNN 440 VYIFPGVALA 450 VILCNTRHIS 460 DHVFLEAAKA 470 LTSQLTDKEL 480 AQGRLYPPLA 490 NIQEVSINIA 500 IKVTEYLYAN 510 KMAFRYPEPE 520 DKARYIRERI 530 WRSEYDSLLP 540 DVYEWPESAS HPPQITE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051287	NAD binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.