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Overview

Uniprot ID	F1RQH2
Protein Name	Pre-mRNA-processing factor 40 homolog A
Gene Name	PRPF40A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
102	LLSKCPWKEYKSDSG

Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing

Protein Sequence

10 HWEIRLSPQT 20 SIFFLQIYMY 30 MPGMMSSVMP 40 GMMMSHMSQA 50 SMQPALPPGV 60 NNMDVAKSMW 70 TEHKSPDGRT 80 YYYNTETKQS 90 TWEKPDDLKT 100 PAEQLLSKCP 110 WKEYKSDSGK 120 PYYYNSQTKE 130 SRWAKPKELE 140 DLEGYQNTIV 150 AGSLITKSNL 160 HGELKQEECT 170 TTSAAPVPTT 180 EIPTTMSTMA 190 AAEAAAAVVA 200 AAAAAAAAAA 210 AANASASTSA 220 SSTVGGTVPV 230 VPEPEVTSIV 240 ATVVDNENTV 250 TISTEEQAQL 260 TSTPAVQDQS 270 VEVSSNTGEE 280 TSKQEAVADF 290 TPKKEEEENQ 300 PAKKTYTWNT 310 KEEAKQAFKE 320 LLKEKRVPSN 330 ASWEQAMKMI 340 INDPRYSALA 350 KLSEKKQAFN 360 AYKVQTEKEE 370 KEEARSKYKE 380 AKESFQRFLE 390 NHEKMTSTTR 400 YKKAEQMFGE 410 MEVWNAISER 420 DRLEIYEDVL 430 FFLSKKEKEQ 440 AKQLRKRNWE 450 ALKNILDNMA 460 NVTYSTTWSE 470 AQQYLMDNPT 480 FAEDEELQNM 490 DKEDALICFE 500 EHIRALEKEE 510 EEEKQKSLLR 520 ERRRQRKNRE 530 SFQIFLDELH 540 EHGQLHSMSS 550 WMELYPTISS 560 DIRFTNMLGQ 570 PGSTALDLFK 580 FYVEDLKARY 590 HDEKKIIKDI 600 LKDKGFVVEV 610 NTTFEDFVAI 620 ISSTKRSTTL 630 DAGNIKLAFN 640 SLLEKAEARE 650 REREKEEARK 660 MKRKESAFKS 670 MLKQATPPIE 680 LDAVWEDIRE 690 RFVKEPAFED 700 ITLESERKRI 710 FKDFMHVLEH 720 ECQHHHSKNK 730 KHSKKSKKHH 740 RKRSRSRSVR 750 KDFFLLEQFI 760 HQNANIFYLT 770 QDSPESDAER 780 EKDKKEKDRE 790 SEKDRTRQRS 800 ESKHKSPKKK 810 TGKDSGNWDT 820 SGSELSEGEL 830 EKRRRTLLEQ LDDDQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0016607	nuclear speck
Biological Process	GO:0045292	mRNA cis splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.