Search Results

Overview

Uniprot ID	F1RQZ0
Protein Name	Progranulin
Gene Name	GRN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
407	KGHTCVGKGHCKRKK
492	VKARTCEKEEDSALP
62	QHLGVPCKTKAQCPP

Function

Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8

Protein Sequence

10 MWTLVSWVAL 20 VTGLVAGTQC 30 PDGQLCPVAC 40 CLDPGGASYS 50 CCNPVPDKWP 60 KALSQHLGVP 70 CKTKAQCPPG 80 HSCILTTNET 90 SNCCPFPEAV 100 SCRDGLHCCP 110 QGFHCSADGW 120 SCLRRPDTKP 130 SDDILCPNSQ 140 FHCPNSSTCC 150 TMLDGSWGCC 160 PMPQASCCGD 170 KVHCCPHGTS 180 CDLAHSRCLT 190 VTNTHPMAKI 200 PSQETIKTAV 210 QCPDAESQCH 220 NNSTCCKLSS 230 GKYGCCPLPN 240 ATCCSDHIHC 250 CPHGFVCDPV 260 KKKCFSKENE 270 AIDFFTKLPA 280 HSVQEVKCDT 290 EVSCPDDYTC 300 CRLQSGKWGC 310 CPFVQAVCCN 320 DHVHCCPTGY 330 QCNIEKGTCD 340 LETQWVPWKE 350 KIPASLSRPD 360 LLAMERDVPC 370 DNVSSCPSSS 380 TCCPVTPGEW 390 GCCPAPEAVC 400 CSDHQYCCPK 410 GHTCVGKGHC 420 KRKKDMVTGL 430 NKMPTRRASA 440 SQPGNTTGCD 450 QHTSCPVGQT 460 CCPSLSKGWA 470 CCQLPHAVCC 480 EDRQHCCPAG 490 YTCNVKARTC 500 EKEEDSALPA 510 THLARVGDVA 520 CGERRFCHNN 530 YTCCRDSLGG 540 WACCPYRQGI 550 CCADGRHCCP 560 AGFRCGARGT 570 KCLHKEALRW 580 DAPLRDPAPR QLL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005764	lysosome
Molecular Function	GO:0005125	cytokine activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.