Search Results

Overview

Uniprot IDF1RRD7
Protein NameCLIP-associating protein 1
Gene NameCLASP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1345 TIRALALKVLREILR
1496 KLLNLYIKRAQTGSG
240 ILSVCKDKSFDDEES

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRSMEYFS 20 AQVQQKDVGG 30 RLQVGQELLL 40 YLGVPGAIPD 50 LEENLGCLGK 60 TVDALTGWVG 70 SSNYRVSLMG 80 LEILSAFVDR 90 LSTRFKSYVA 100 MVIVALIDRL 110 GDAKDKVRDK 120 TQALILKLMD 130 QVAPPMYIWE 140 QLASGFKHKN 150 SQSREGVCLC 160 LIETLNVFGA 170 QPLVLSKLVP 180 HLCILFGDYN 190 SQVRDAATLA 200 IVEIYRHVGD 210 KVRMDLYKKG 220 IPPARLETIL 230 AKFDEVQNSG 240 GMILSVCKDK 250 SFDDEESVDG 260 NRPSSAASAF 270 KVPAPKTSGN 280 PVNSARKPGS 290 AGGPKVGAGA 300 SKEGGAGAVD 310 EDDFIKAFTD 320 VPSIQIYSSR 330 ELEETLNKIR 340 EILSDDKHDW 350 DQRANALKKI 360 RSLLVAGAAQ 370 YDCFFQHLRL 380 LDGALKLSAK 390 DLRSQVVREA 400 CITVAHLSTV 410 LGNKFDHGAE 420 AIVPTLFNLV 430 PNSAKVMATS 440 GCAAIRFIIR 450 HTHVPRLIPL 460 ITSNCTSKSV 470 PVRRRSFEFL 480 DLLLQEWQTH 490 SLERHAAVLV 500 ETIKKGIHDA 510 DAEARVEARK 520 TYMGLRNHFP 530 GEAETLYNSL 540 EPSYQKSLQT 550 YLKSSGSVAS 560 LPQSDRSSSS 570 SQESLNRPFS 580 SKWSTANPST 590 VAGRVSTGSS 600 KANSLPGSLQ 610 RSRSDIDVNA 620 AAGAKAHHAA 630 GQSVRSGRLG 640 AGALNPGSYA 650 SLEDTSDKMD 660 GTASDDGRVR 670 AKLSAPLAGM 680 GSAKTDTRGR 690 SRTKMVSQSQ 700 PGSRSGSPGR 710 VLTTTALSTV 720 SSGVQRVLVN 730 SASAQKRSKI 740 PRSQGCSREA 750 SPSRLSVARS 760 SRIPRPSVSQ 770 GCSREASRES 780 SRDTSPVRSF 790 QPLGPGYGIS 800 QSSRLSSSVS 810 AMRVLNTGSD 820 VEEAVADALL 830 LGDIRTKKKP 840 ARRRYESYGM 850 HSDDDANSDA 860 SSACSERSYS 870 SRNGSIPTYM 880 RQTEDVAEVL 890 NRCASSNWSE 900 RKEGLLGLQN 910 LLKNQRTLSR 920 VELKRLCEIF 930 TRMFADPHGK 940 GVFSMFLETL 950 VDFIQVHKDD 960 LQDWLFVLLT 970 QLLKKMGADL 980 LGSVQAKVQK 990 ALDVTRESFP 1000 NDLQFNILMR 1010 FTVDQTQTPS 1020 LKVKVAILKY 1030 IETLAKQMDP 1040 GDFINSSETR 1050 LAVSRVITWT 1060 TEPKSSDVRK 1070 AAQSVLISLF 1080 ELNTPEFTML 1090 LGALPKTFQD 1100 GATKLLHNHL 1110 RNTGNGTQGS 1120 MGSPLTRPTP 1130 RSPANWSSPL 1140 TSPTNTSQNT 1150 LSPSAFDYDT 1160 ENMNSEDIYS 1170 SLRGVTEAIQ 1180 NFSFRSQEDM 1190 NEPLKRESKK 1200 DDVDSMCGGP 1210 GMSDPRAGGD 1220 ATDSSQTALD 1230 NKASLLHSMP 1240 AHSSPRSRDY 1250 NPYNYSDSIS 1260 LFNKSALKEA 1270 MFDDDADQFP 1280 DDLSLDHSDL 1290 VAELLKELSN 1300 HNERVEERKI 1310 ALYELMKLTQ 1320 EESFSVWDEH 1330 FKTILLLLLE 1340 TLGDKEPTIR 1350 ALALKVLREI 1360 LRHQPARFKN 1370 YAELTVMKTL 1380 EAHKDPHKEV 1390 VRSAEEAASV 1400 LATSISPEQC 1410 IKVLCPIIQT 1420 ADYPINLAAI 1430 KMQTKVIERV 1440 SKETLNLLLP 1450 EIMPGLIQGY 1460 DNSESSVRKA 1470 CVFCLVAVHA 1480 VIGDELKPHL 1490 SQLTGSKMKL 1500 LNLYIKRAQT 1510 GSGGGDPTTD VSGQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005819 spindle
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0007026 negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.