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Overview

Uniprot ID	F1RRN0
Protein Name	Inactive tyrosine-protein kinase 7
Gene Name	PTK7
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1060	QPEGCPSKLYRLMQR
954	SNNRFVHKDLAARNC

Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis

Protein Sequence

10 MGAARGALSS 20 PRRLPLLSVL 30 LLPLLGGMQV 40 TCVRTVAATP 50 LTMLLPCSPS 60 AGAQAVIVFI 70 KEPSSQDALQ 80 GRRALLRCEV 90 EAPGPVHVYW 100 LLDGAPVEDT 110 ERRFAQGSSL 120 SFTAVDRLQD 130 SGAFQCVARD 140 DATGEEARSA 150 NASFNIKWIE 160 TGPVLLKHPA 170 SEAEIQPQTQ 180 VTLRCHIDGH 190 PRPTYQWFRD 200 GSPLADGQSN 210 HTVSSKERNL 220 TLRPASPEHS 230 GTYSCCAHNA 240 FGQACSSQNF 250 TLNIADESFA 260 RVMLAPQDVV 270 VARNEEAMFH 280 CQFSAQPPPS 290 LQWVFEDETP 300 ITNRSRPPHL 310 RRATVFANGS 320 LLLTQVRPRN 330 AGVYRCIGQG 340 QRGPPVVLEA 350 TLHLAEIEDM 360 APFEPRVFTA 370 GSEERVACTP 380 PQGLPAPLVW 390 WEHEGNRLPT 400 HGRVSQQGHE 410 LVFASTAESD 420 AGVYTCHAAN 430 LAGQRHQDVN 440 ITVATVPTWL 450 KKPQDSQLEE 460 GKPGYLHCLT 470 QATPKPTVVW 480 YRNQMLISED 490 SRFEVSKNGT 500 LRINSVEVYD 510 GTWYRCVSST 520 PAGSIEAQAR 530 VQVLEKLKFT 540 PPPRPQQCME 550 FDKEATVPCS 560 ATGREKPTIK 570 WVRADGSSLP 580 EWVTDNAGTL 590 HFSRVTRDDA 600 GNYTCIASNG 610 LQGQIRAHVQ 620 LTVAVFITFK 630 VEPERTTVYQ 640 GHTALLRCEA 650 QGDPKPLIQW 660 KGKDRILDPT 670 KLGPRMHIFQ 680 NGSLVIHDVA 690 PEDSGRYTCI 700 AGNSCNIKHT 710 EAPLYVVDKP 720 VPEESEGPGS 730 PPPYKMIQTI 740 GLSVGAAVAY 750 IIAVLGLMFY 760 CKKRCKAKRL 770 QKQPEGEEPE 780 MECLNGGPLQ 790 NGQPSAEIQE 800 EVALTSLGSG 810 SAAANKRHST 820 SDKMHFPRAS 830 LQPITTLGKS 840 EFGEVFLAKA 850 QGLEEGVAET 860 LVLVKSLQSR 870 DEQQQLDFRR 880 ELEMFGKLSH 890 PNVVRLLGLC 900 REAEPHYMVL 910 EYVDLGDLKQ 920 FLRISKSKDE 930 KLKSQPLSTK 940 QKVALCAQVA 950 LGMEHLSNNR 960 FVHKDLAARN 970 CLVSAQRQVK 980 VSALGLSKDV 990 YNSEYYHFRQ 1000 AWVPLRWMSP 1010 EAILEGDFST 1020 KSDVWAFGVL 1030 MWEVFTHGEM 1040 PHDGQADDEV 1050 LADLQAGKAR 1060 LPQPEGCPSK 1070 LYRLMQRCWA 1080 LSPKDRPSFS 1090 EIANALGDSS ADSKP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0005911	cell-cell junction
Cellular Component	GO:0043025	neuronal cell body
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008046	axon guidance receptor activity
Molecular Function	GO:0004672	protein kinase activity
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0016477	cell migration
Biological Process	GO:0071300	cellular response to retinoic acid
Biological Process	GO:0007156	homophilic cell-cell adhesion
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway
Biological Process	GO:0050808	synapse organization
Biological Process	GO:0016055	Wnt signaling pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.