Search Results

Overview

Uniprot IDF1RS73
Protein NameRho GTPase-activating protein 10
Gene NameARHGAP10
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
425 RVVGVSSKVQRLLSM

Function

GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins

Protein Sequence

10 MGLQPLEFSD 20 CYLDSPWFRE 30 RIRAHEAELE 40 RTNKFIKELI 50 KDGKNLIAAT 60 KNLSAAQRKF 70 AHSLRDFKFE 80 FIGDAETDDE 90 RCIDASLREF 100 SNFLKNLEEQ 110 REIMALSVTE 120 TLIKPLEKFR 130 KEQLGAVKEE 140 KKKFDKETEK 150 NYSLIDKHLN 160 LSAKKKDSHL 170 QEADIQVEQN 180 RQHFYELSLE 190 YVCKLQEIQE 200 RKKFEFVEPM 210 LSFFQGMFTF 220 YHQGHELAKD 230 FNHYKMELQI 240 NIQNTRNRFE 250 GTRSEVEELM 260 NKIRQNPKDH 270 KRASQFTAEG 280 YLYIQEKRPP 290 PFGSSWVKHY 300 CMYRKAAKKL 310 NIIPFEHRSG 320 GKLGDGEVFF 330 LKECTRRHAD 340 SIDRRFCFDV 350 ETADRPGVSL 360 TMQAFSEEER 370 KQWLEALGGK 380 EALFHSFNRA 390 IVPRPEGSAQ 400 LDKMGFTILR 410 KCISAVETRG 420 INDQGLYRVV 430 GVSSKVQRLL 440 SMLMDVKTCN 450 EVDLENSPDW 460 EVKTITSALK 470 QYLRSLPEPL 480 MTYELHGDFI 490 VPAKSGSPES 500 RVNAIHFLVH 510 KLPEKNKEML 520 DILVKHLTNV 530 SNHSKQNLMT 540 VANLGVVFGP 550 TLMRPQEETV 560 AAIMDLKFQN 570 IVVEILIENH 580 EKIFRTLPDA 590 TLPEPVSLST 600 SPPNAPPRQS 610 KRQGQRTKRP 620 VAVYNLCLEL 630 EDVDNARLPK 640 EDTPPSSLDS 650 LSSPSSTAAA 660 AHGPPGPDRN 670 HLLTDGGSFE 680 DWPSTVPSQA 690 RPSTVQWLNP 700 QSPTTPSCNP 710 ALTPPSPKLS 720 PFPLSLPATI 730 VDKPPESVIN 740 RKARAVYPCE 750 AEHSSELSFE 760 IGAIFEDVQT 770 SREPGWLEGT 780 LNGKRGLIPQ NYVKLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005096 GTPase activator activity
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0007165 signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.