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Overview

Uniprot IDF1RSG8
Protein Name-
Gene NameTCEA1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
19 MDKMVQKKNAAGALD
85 TCGKCKKKNCTYTQV

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus

Protein Sequence

10 MDDEVVRIAK 20 KMDKMVQKKN 30 AAGALDLLKE 40 LKNIPMTLEL 50 LQEMASDELK 60 EMRKNLTKEA 70 IREHQMAKTG 80 GTQTDLFTCG 90 KCKKKNCTYT 100 QVQTRSADEP 110 MTTFVVCNEC 120 GNRWKVRHFL 130 GFPFPPFAWG 140 GFCSGLGQPG 150 PSACVRACMR 160 APTARCWGER 170 GRRVLGHTVC CPAGNEAC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003676 nucleic acid binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.