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Overview

Uniprot IDF1RSZ3
Protein NameLong-chain-fatty-acid--CoA ligase
Gene NameACSL1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
430 IQSSLGGKVRLMVTG

Function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation

Protein Sequence

10 IIGHRQPRMM 20 QAHELFRYFR 30 MPELVDFQQY 40 VRTLPTNTLM 50 GFGAFAALTT 60 FWYATRPRAL 70 KPPCDLAMQS 80 VEVAGSDGAR 90 RSAILDSDEP 100 LAYFYDDVRT 110 LYEGFQRGIR 120 VSNNGPCLGS 130 RKPDQPYEWL 140 SYKQVEDMSE 150 CVGSALIHKG 160 FKAGPENFVG 170 IFAQNRPEWV 180 IIEQGCFAYS 190 MVVVPLYDTL 200 GTEAITYIIN 210 KGELSLVFVD 220 KPEKANLLLE 230 GVENKLIPGL 240 KTIILMDSYG 250 IDLLERGKKC 260 GVEIMSMKAL 270 EVSHPAPPAP 280 EDLAVICFTS 290 GTTGNPKGAM 300 ITHRNVVSDC 310 SAFVKVTEKT 320 FSPSSDDTLI 330 SFLPLAHMFE 340 RVVECVMLCH 350 GAKIGFFQGD 360 IRLLMDDLKA 370 LQPTIFPVVP 380 RLLNRMFDRI 390 FGQANTTLKR 400 WLLDFASKRK 410 EAELRSGIIR 420 NNSLWDKLIF 430 HKIQSSLGGK 440 VRLMVTGAAP 450 VSATVLTFLR 460 AALGCQFYEG 470 YGQTECTAGC 480 SLTVPGDWTA 490 GHVGAPMPCS 500 LIKLVDVEEM 510 NYLAAKGEGE 520 VCVKGPNVFQ 530 GYLKDPAKTA 540 EALDKDGWLH 550 TGDIGKWLPN 560 GTLKIIDRKK 570 HIFKLAQGEY 580 IAPEKIENIY 590 LRSEPVAQVF 600 VHGESLQAFL 610 IAIVVPDVET 620 LGHWAQKRGF 630 VGSFEELCRN 640 KDVKKAILED 650 MLRLGRDAGL 660 KSFEQVRGIS 670 LHPELFSIDN 680 GLLTPTMKAK 690 RPELRNYFRS 700 QIDELYSTVK V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Molecular Function GO:0047676 arachidonate-CoA ligase activity
Molecular Function GO:0005524 ATP binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.