Search Results

Overview

Uniprot ID	F1RTV5
Protein Name	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Gene Name	PAICS
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
108	IATGSFLKRNPGVKE
78	IKTAFTRKCGETAFI

Function

Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway

Protein Sequence

10 LSTLLNIGKK 20 LYEGKTKEVY 30 ELLDSPGKVL 40 LQSKDQITAG 50 NAARKNHLEG 60 KAAISNTITS 70 CVFQLLQEAG 80 IKTAFTRKCG 90 ETAFIAPKCE 100 MIPIEWVCRR 110 IATGSFLKRN 120 PGVKEGYKFY 130 PPKVEMFFKD 140 DANNDPQWSE 150 EQLIAANFCF 160 AGLVIGQTEV 170 DVMSHATQAI 180 FEILEKSWLP 190 QNCTLVDMKV 200 QIQWRFEKIV 210 LADVIDNDSW 220 RLWPSGDRSQ 230 QKDKQSYRDL 240 KEVTPEGLQM 250 VKKNFEWVAE 260 RVELLLKTES 270 QCRVVVLMGS 280 TSDLSHCEKI 290 KKACGNFGIP 300 CELRVTSAHK 310 GPDETLRIKA 320 EYEGDGIPTV 330 FVAVAGRSNG 340 LGPVMSGNTA 350 FPVISCPPLS 360 PDWGAQDVWS 370 SLRLPSGLGC 380 STILSPEGSA 390 QFAAQIFGLN 400 NHLVWAKLRA 410 NVLNTWISLK 420 QADKKIREGN L

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004638	phosphoribosylaminoimidazole carboxylase activity
Molecular Function	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Biological Process	GO:0006189	'de novo' IMP biosynthetic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.