Search Results

Overview

Uniprot IDF1RU09
Protein NameNuclear receptor coactivator
Gene NameNCOA2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
684 STHGTSLKEKHKILH

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer

Protein Sequence

10 MSGMGENTSD 20 PSRAETRKRK 30 ECPDQLGPSP 40 KRSTEKRNRE 50 QENKYIEELA 60 ELIFANFNDI 70 DNFNFKPDKC 80 AILKETVKQI 90 RQIKEQEKAA 100 AANIDEVQKS 110 DVSSTGQGVI 120 DKDALGPMML 130 EALDGFFFVV 140 NLEGNVVFVS 150 ENVTQYLRYN 160 QEELMNKSVY 170 SILHVGDHTE 180 FVKNLLPKSI 190 VNGGSWSGEP 200 PRRSSHTFNC 210 RMLVKPLPDP 220 EEEGHDNQEA 230 HQKYETMQCF 240 AVSQPKSIKE 250 EGEDLQSCLI 260 CVARRVPMKE 270 RPVLPSSESF 280 TTRQDLQGKI 290 TSLDTSTMRA 300 AMKPGWEDLV 310 RRCIQKFHAQ 320 HEGESVSYAK 330 RHHHEVLRQG 340 LAFSQIYRFS 350 LSDGTLVAAQ 360 TKSKLIRSQT 370 TNEPQLVISL 380 HMLHREQNVC 390 VMNPDLTGQA 400 VGKPLNPLSS 410 SSPAHQAMCS 420 GNPGQDMTLS 430 SNINFPINGP 440 KEQMGMPMGR 450 FGGSGGMNHV 460 SSMQATTPQG 470 SNYALKMNSP 480 SQSSPGMTPG 490 QPSSMLSPRH 500 RMSPGVAGSP 510 RIPPSQFSPA 520 GSLHSPVGVC 530 SSTGNSHSYA 540 NSSLNALQAL 550 SEGHGVSLGS 560 SLASPDLKTG 570 NLQNSPVNMN 580 PPPLSKMGSL 590 DSKDCFGLYG 600 EPSEGTTGQA 610 ESSGHPGEQK 620 EAGEPGLPPA 630 VGSERPDGQS 640 RLHDSKGQTK 650 LLQLLTTKSD 660 QMEPSPLASS 670 LSDATKDSVG 680 SLPGSGSTHG 690 TSLKEKHKIL 700 HRLLQDSSSP 710 VDLAKLTAEA 720 TGKELNQEAS 730 STAPGSEVTI 740 KQEPVSPKKK 750 ENALLRYLLD 760 KDDTKDIGLP 770 EITPKLERLD 780 SKTDPASNTK 790 LIAMKTEKEE 800 MSFEPSDQPG 810 SELDNLEEIL 820 DDLQNSQLPQ 830 LFPDTRPGAP 840 AGSVDKQAII 850 NDLMQLTAEN 860 SPVTPVGAQK 870 TALRISQSSM 880 IGSNAARPAM 890 PSGEWAPQTS 900 AVRVTCAATT 910 GAMNRPIQGG 920 MIRNPTASIP 930 MRPSSQPGQR 940 QMLQPQVMNI 950 GPSELEMNMG 960 PQYSQQQAPP 970 NQTAPWPESI 980 LPIDQAPFAS 990 QNRQPFGSSP 1000 DDLLCPHPAA 1010 ESPSDEGALL 1020 DQLYLALRNF 1030 DGLEEIDRAL 1040 GIPELVSQSQ 1050 AVDPEQFSSQ 1060 DSNMMLEQKA 1070 PVFPQQYASQ 1080 AQMAPGSYAP 1090 MQDPNFHTMG 1100 QRPSYATLRM 1110 QPRPGLRPTG 1120 LVQNQPNQLR 1130 LQLQHRLQAQ 1140 QNRQPLMNQI 1150 SNVSNVNLTL 1160 RPGVPTQAPI 1170 NAQMLAQRQR 1180 EILNQHLRQR 1190 QMHQQQQVQQ 1200 RTLMMRGQGL 1210 NMTPSVVAPG 1220 GVPAAMSNPR 1230 LPQANAQQFP 1240 FPPNYGMSQQ 1250 PDPGFTGAAA 1260 PQSPLMSPRM 1270 AHTQSPMLQQ 1280 SQPNPAYQAS 1290 SDMNGWAQGS 1300 MGGNSMFSQQ 1310 SPPHFGPQAN 1320 TSMYNNNMNI 1330 SVSMATSTGG 1340 MSNMNQMTGQ 1350 ISMTSVTSVP 1360 TSGLSSMGPE 1370 QVNDPALRGG 1380 SLFPNQLPGM 1390 DMIKQEGDAS 1400 RVRSSREMNV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0017162 aryl hydrocarbon receptor binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0046983 protein dimerization activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0140416 transcription regulator inhibitor activity
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0019216 regulation of lipid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.