Search Results
Overview
| Uniprot ID | F1RVH7 |
|---|---|
| Protein Name | Insulin-like growth factor-binding protein 7 |
| Gene Name | IGFBP7 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | VSGVCVCKSRYPVCG |
| 146 | RAESRGEKAVTQVSK |
| 153 | KAVTQVSKGTCEQGP |
| 97 | SRKRRKGKAGAAAGG |
Function
Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis
Protein Sequence
10
MERPPLPALL
20
LGAAGLLLLL
30
LPLSSSSSSD
40
ACGPCEPATC
50
PPLPPRGCPL
60
GETRDACGCC
70
PVCARGEGEP
80
CGGGGAGRGH
90
CAPGMECVKS
100
RKRRKGKAGA
110
AAGGPGVSGV
120
CVCKSRYPVC
130
GSDGVTYPSG
140
CQLRAASLRA
150
ESRGEKAVTQ
160
VSKGTCEQGP
170
SIVTPPKDIW
180
NVTGAQVYLS
190
CEVIGIPTPA
200
LIWNKVQRGH
210
YGVQRTELLP
220
GDRDNLAIQT
230
RGGPEKHEVT
240
GWVLISPLSK
250
EDAGEYECHA
260
ANSQGQASAS
270
AKITVVDTLH
EIPVKKGR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0005520 | insulin-like growth factor binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0001558 | regulation of cell growth |
| Biological Process | GO:0009966 | regulation of signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.