Search Results

Overview

Uniprot IDF1RVS1
Protein NameCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Gene NameCMTR1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
108 KEGEGLGKYSQGRKD
114 GKYSQGRKDIVEASN
123 IVEASNQKGRRGLGL
449 YVVCKGLKVGTDDVR

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1)

Protein Sequence

10 MKRRNDPECT 20 APIKKQKKRV 30 AELALSLSST 40 SDDEPPSSVN 50 HAAKACATSL 60 SGSDSETEGK 70 QRSSGSFDDA 80 FKADSLVEGT 90 SSRYSMYNSV 100 SQKLMAKMGF 110 KEGEGLGKYS 120 QGRKDIVEAS 130 NQKGRRGLGL 140 TLQGFDQELN 150 VDWRAEPEPS 160 ACEQVSWFPE 170 CTTEIPDTQE 180 MSDWMVVGKR 190 KMIIEDETEF 200 CGEELLHSVL 210 QCKSVFDVLD 220 GEEMRRARTR 230 ANPYEMIRGV 240 FFLNRAAMKM 250 ANMDFVFDRM 260 FTNPRDSYGK 270 PLVKNREAEL 280 LYFADVCAGP 290 GGFSEYVLWR 300 KKWHAKGGMT 310 LKGPNDFKLE 320 DFYSASSELF 330 EPYYGEGGID 340 GDGDITRPEN 350 ITAFRNFVLD 360 NTDRKGVHFL 370 MADGGFSVEG 380 QENLQEILSK 390 QLLLCQFLMA 400 LSVVRTGGHF 410 ICKTFDLFTP 420 FSVGLIYLLY 430 CCFERVCLFK 440 PITSRPANSE 450 RYVVCKGLKV 460 GTDDVRDYLF 470 SVNIKLNQLR 480 NSESDVNLVV 490 PLEVIKGDHE 500 FTDYMIRSNE 510 SHCSLQIKAL 520 AKIHAFVQDT 530 TLSEPRQAEI 540 RKECLRLWGI 550 PDQARVAPSS 560 TDPKSKFFEL 570 IQGTEIDIFS 580 YKPTLLTSKT 590 LEKIRPVLDY 600 RCMVSGSEQK 610 FLIGLGKSQI 620 YTWDGRQSDR 630 WVKLDLKTEL 640 PRDTLLSVEI 650 VHELKGEGKA 660 QRKISAIHIL 670 DVLVLNGSDV 680 REQHFNQRIQ 690 LAEKFVKAVS 700 KPSRPDMNPI 710 RVKEVYRLEE 720 MEKIFVRLEM 730 KIIKGSGGTP 740 KLSYTGRDDR 750 HFVPTGLYIV 760 RTVNEPWTMA 770 FSKSFKRKFF 780 YNKKTKDSTF 790 DLPAEAIAPF 800 HICYFGRLFW 810 EWGDGIRVHD 820 SQKPQDPDKL 830 SKEDVLSFIQ THSA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004483 methyltransferase cap1 activity
Molecular Function GO:0003676 nucleic acid binding
Biological Process GO:0006370 7-methylguanosine mRNA capping
Biological Process GO:0032259 methylation
Biological Process GO:0016556 mRNA modification

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.