Search Results
Overview
| Uniprot ID | F1RVZ1 |
|---|---|
| Protein Name | Acyl-coenzyme A oxidase |
| Gene Name | ACOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 257 | EAARCLSKACTIAIR |
Function
Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2))
Protein Sequence
10
MILSDPDLQH
20
EDLNFLSRSQ
30
RYEVAVKKSA
40
TTVKKIREFG
50
LADPDEILWF
60
KKLHLVNFVE
70
PVGLNYSMFI
80
PTLLSQGTTA
90
QREKWLPPSK
100
RLEIIGTYAQ
110
TELGHGTHLR
120
GLETTATYDP
130
ATEEFILNSP
140
TVTSIKWWPG
150
GLGKTSNHAI
160
VLAQLITQGK
170
CYGLHAFIVP
180
IREQGTHKPL
190
PGITVGDIGP
200
KFGYDEMDNG
210
YLKMDNYRIP
220
RENMLMKYAQ
230
VKPDGTYVKP
240
LSNKLTYGTM
250
VFIRSFLVGE
260
AARCLSKACT
270
IAIRYSAVRH
280
QSELRPDEPE
290
PQILDYQTQQ
300
YKLFPFLATA
310
YAFQFVGAYI
320
KETYHRINEN
330
IRQGDLSGLP
340
ELHALTAGLK
350
AFTSWTANAA
360
IEACRMACGG
370
HGYSHCSGLP
380
NIYVNFTPTC
390
TFEGENTVMM
400
LQTARFLMKS
410
YNQVHSGKLV
420
CGMVSYLNDL
430
PSQRIQPQQV
440
AAWPTVADIN
450
SPDSLIEAYR
460
LRASRLVEIA
470
AKNLQTEMSH
480
RKSKEAAWNL
490
TSIDLVRASE
500
AHCHYVVVKL
510
FAEKLHQIQE
520
RSIHAVLRNL
530
CLLYALYGIS
540
QNSGDFLQGS
550
IMTESQVTHV
560
NERVKELLMA
570
IRPEAVALVD
580
AFDFQDVTLG
590
SVLGRYDGNV
600
YENMFEWAKK
610
SPLNKTEVKS
620
KNSFSPFLKS
FI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0003997 | acyl-CoA oxidase activity |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.