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Overview

Uniprot IDF1RWL2
Protein NameMediator of RNA polymerase II transcription subunit 1
Gene NameMED1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1307 SLTAVIDKLKHGVVT

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Protein Sequence

10 MKAQGETEES 20 EKLSKMSSLL 30 ERLHAKFNQN 40 RPWSETIKLV 50 RQVMEKRVVM 60 SSGGHQHLVS 70 CLETLQKALK 80 VTSLPAMTDR 90 LESIARQNGL 100 GSHLSASGTE 110 CYITSDMFYV 120 EVQLDPAGQL 130 CDVKVAHHGE 140 NPVSCPELVQ 150 QLREKNFDEF 160 SKHLKGLVNL 170 YNLPGDNKLK 180 TKMYLALQSL 190 EQDLSKMAVM 200 YWKATNAGPL 210 DKILHGSVGY 220 LTPRSGGHLM 230 NLKYYASPSD 240 LLDDKTTSPI 250 ILHENNVPRS 260 LGMNASVTIE 270 GTSAMYKLPI 280 APLIMGSHPV 290 DNKWTPSFSS 300 ITSANSVDLP 310 ACFFLKFPQP 320 IPVSRAFVQK 330 LQNCTGIPLF 340 ETQPTYVPLY 350 ELITQFELSK 360 DPDPVPLNHN 370 MRFYAALPGQ 380 QHCYFLNKDA 390 PLPDGRSLQG 400 TLVSKITFQH 410 PGRVPLILNL 420 IRHQVAYNTL 430 IGSCVKRTIL 440 KEDSPGLLQF 450 EVCPLSESRF 460 SVSFQHPVND 470 SLVCVVMDVQ 480 DSTHVSCKLY 490 KGLSDALICT 500 DDFIAKVVQR 510 CMSIPVTMRA 520 IRRKAETIQA 530 DTPALSLIAE 540 TVEDMVKKNL 550 PPASSPGYGM 560 TTGNNPMSGT 570 TTPTNTFPGG 580 PITTLFNMSM 590 SIKDRHESVG 600 HGEDFSKVSQ 610 NPILTSLLQI 620 TGNGGSTIGS 630 SPTPPHHTPP 640 PVSSMAGNTK 650 NHPMLMNLLK 660 DNPAQDFSTL 670 YGSSPLERQN 680 SSSGSPRMEM 690 CSGSNKTKKK 700 KSSRLPPDKP 710 KHQTEDDFQR 720 ELFSMDVDSQ 730 NPIFDVNMTA 740 DTLDTPHITP 750 APSQCSTPPT 760 TYPQPVPHPQ 770 PSIQRMVRLS 780 SSDSIGPDVT 790 DILSDIAEEA 800 SKLPSTSDDC 810 PPIGTPVRDS 820 SSSGHSQSAL 830 FDPDVFQTNN 840 NENPYTDPAD 850 LIADAAGSPS 860 SDSPTNHFFP 870 DGVDFNPDLL 880 NSQSQSGFGE 890 EYFDESSQSG 900 DNDDFKGFAS 910 QALNTLGVPM 920 LGGDNGESKF 930 KSNSQADTVD 940 FSIIAVAGKA 950 LGPADLMEHH 960 SGSQSPLLTT 970 GDLGKEKTQK 980 RVKEGNGTSN 990 SSLSGPGLDS 1000 KPGKRSRTPS 1010 NDGKNKDKPP 1020 KRKKADTEGK 1030 SPSHSSSNRP 1040 FTPPTSTGGS 1050 KSPGSSGRSQ 1060 TPPGVATPPI 1070 PKITIQIPKG 1080 TVMVGKPSSH 1090 SQYTSSGSVS 1100 SSGSKSHHSH 1110 SSSSSASNSG 1120 KMKSSKSEGS 1130 SSSKLSSSIY 1140 SSQGSSGSSQ 1150 SKTSSQSGGK 1160 PGSSPITKHG 1170 LSSGSSSTKM 1180 KPQGKPSSLM 1190 NPSLSKPNIS 1200 PSHSRPPGGS 1210 DKLASPMKPV 1220 PGTPPSSKAK 1230 SPISSGSGGS 1240 HMSGTSSSTG 1250 MKSSSGLGSS 1260 GSLSQKNPPS 1270 SNSCTASSSS 1280 FSSSGSSMSS 1290 SQNQHGSSKG 1300 KSPSRNKKPS 1310 LTAVIDKLKH 1320 GVVTSGPGSE 1330 DSMDGQVGVS 1340 TNSSSHPMSS 1350 KHSMSGGEFQ 1360 GKREKSDKDK 1370 SKVSTSGGSV 1380 DSSKKTSESK 1390 NVGSTGVAKI 1400 IISKHDGGSP 1410 SIKAKVTLQK 1420 PGESSGEGLR 1430 PQMASSKNYG 1440 SPLISGSTPK 1450 HERGSPSHSK 1460 SPAYTPQNLD 1470 SESESGSSIA 1480 EKSYQNSPSS 1490 DDGIRPLPEY 1500 STEKHKKHKK 1510 EKKKVKDKDR 1520 DRDRDRDRDK 1530 KKSHSIKPES 1540 WSKSPISSDQ 1550 SLSMTSNTIL 1560 STDRPSRLSP 1570 DFMIGEEDDD LMDVALIGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0050693 LBD domain binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0042974 nuclear retinoic acid receptor binding
Molecular Function GO:0046966 nuclear thyroid hormone receptor binding
Molecular Function GO:0042809 nuclear vitamin D receptor binding
Molecular Function GO:0042975 peroxisome proliferator activated receptor binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0001223 transcription coactivator binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0001525 angiogenesis
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0097067 cellular response to thyroid hormone stimulus
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0002088 lens development in camera-type eye
Biological Process GO:0035855 megakaryocyte development
Biological Process GO:0042789 mRNA transcription by RNA polymerase II
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010839 negative regulation of keratinocyte proliferation
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0045618 positive regulation of keratinocyte differentiation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0060261 positive regulation of transcription initiation by RNA polymerase II
Biological Process GO:2001141 regulation of RNA biosynthetic process
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0003406 retinal pigment epithelium development
Biological Process GO:0002154 thyroid hormone receptor signaling pathway
Biological Process GO:0003222 ventricular trabecula myocardium morphogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.