Search Results
Overview
| Uniprot ID | F1RX66 |
|---|---|
| Protein Name | Glutathione reductase |
| Gene Name | GSR |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 293 | VLKYSQVKEVKKTSS |
| 434 | EAICKYGKENVKIYS |
| 94 | AAVVESHKLGGTCVN |
Function
Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol
Protein Sequence
10
MALLVWTLSA
20
SAGPSWRQAA
30
RAFSRFAPPP
40
TRPASVFPRA
50
MASRQESQPQ
60
CWPPARSVAT
70
SFDYLVIGGG
80
SGGLASARRA
90
AELGARAAVV
100
ESHKLGGTCV
110
NVGCVPKKVM
120
WNTAVHSEFM
130
HDHVDYGFQS
140
CESKFNWRVI
150
KEKRDAYVSR
160
LNTIYQNNLT
170
KSHIEIIHGH
180
AAFTSDPQPT
190
VEVNGKKYTA
200
PHILIATGGV
210
PSVPPESQIP
220
GASLGITSDG
230
FFQLEELPSR
240
SVIVGAGYIA
250
VEIAGILSAL
260
GSKTSLMIRH
270
DKVLRSFDSI
280
ISSNCTEELE
290
NAGIEVLKYS
300
QVKEVKKTSS
310
GLELCMVTSV
320
PGRKPTFSTI
330
SGVDCLLWAI
340
GRDPNSRGLN
350
LSQLGIQTDD
360
KGHIIVDEFQ
370
NTNVKGIYAV
380
GDVCGRALLT
390
PVAIAAGRKL
400
AHRLFECKED
410
SKLDYDNIPT
420
VVFSHPPIGT
430
VGLTEDEAIC
440
KYGKENVKIY
450
STTFTPMYHA
460
VTKRKTKCVM
470
KMVCANKEEK
480
VVGIHMQGIG
490
CDEMLQGFAV
500
AVKMGATKSD
510
FDNTVAIHPT
SSEELVTLR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004362 | glutathione-disulfide reductase (NADPH) activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0006749 | glutathione metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.