Search Results
Overview
| Uniprot ID | F1RXA7 |
|---|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 3 |
| Gene Name | PSMD3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 269 | NLYDQAEKLVSKSVF |
| 296 | LYYTGRIKAIQLEYS |
| 404 | RLRHNVIKTGVRMIS |
| 455 | EASINHEKGYVQSKE |
| 503 | FPPKSYNKDLESAEE |
| 80 | EDIKEHVKQLEKAVS |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Protein Sequence
10
MKQEGSARRR
20
GTDKAKPPPG
30
GAEQEPPPPP
40
APQDVEMKEE
50
AAAGGASTGE
60
TDGKAAAAAA
70
EHSQRELDTV
80
TLEDIKEHVK
90
QLEKAVSGKE
100
PRFVLRALRM
110
LPSTSRRLNH
120
YVLYKAVHGF
130
FTSNSATRDF
140
LLPFLEEPMD
150
TEADLQFRPR
160
TGKAASAPLL
170
PEVEAYLQLL
180
VVIFLMNSKR
190
YKEAQKISDD
200
LMQKISTQNR
210
RALDLVAAKC
220
YYYHARVYEF
230
LDKLDVVRSF
240
LHARLRTATL
250
RHDADGQATL
260
LNLLLRNYLH
270
YNLYDQAEKL
280
VSKSVFPEQA
290
NNNEWARYLY
300
YTGRIKAIQL
310
EYSEARRTMT
320
NALRKAPQHT
330
AVGFKQTVHK
340
LLIVVELLLG
350
EIPDRLQFRQ
360
PSLKRSLMPY
370
FLLTQAVRTG
380
NLAKFNQVLD
390
QFGEKFQADG
400
TYTLIIRLRH
410
NVIKTGVRMI
420
SLSYSRISLA
430
DIAQKLQLDS
440
PEDAEFIVAK
450
AIRDGVIEAS
460
INHEKGYVQS
470
KEMIDIYSTR
480
EPQLAFHQRI
490
SFCLDIHNMS
500
VKAMRFPPKS
510
YNKDLESAEE
520
RREREQQDLE
530
FAKEMAEDDD
DSFP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0008541 | proteasome regulatory particle, lid subcomplex |
| Molecular Function | GO:0030234 | enzyme regulator activity |
| Biological Process | GO:0042176 | regulation of protein catabolic process |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.