Search Results

Overview

Uniprot ID	F1RXX6
Protein Name	CLIP-associating protein 1
Gene Name	CLASP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
456	ITSNCTSKSVAVRRR

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMEACLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVALLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGTCLC 160 LVATLNASGA 170 HTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMVQSANDKN 250 FDDEDSVDGN 260 RPSSASSTSS 270 KAPPSSRRNV 280 GMGTTRRLGS 290 STVGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIASLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTTSR 590 ASTVSTKSVS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVTSTPGT 630 TPFSSAAALP 640 PGSYASLDGT 650 ATRAEGRIRT 660 RRQSSGSATN 670 VASTPSDSRG 680 RSRAKVVSQS 690 QRSRSANPAG 700 AGSRSSSPGK 710 LLGSGYSGLA 720 GSSSRGPPVT 730 PSSEKRSKIP 740 RSQGCSRETS 750 PSRIGLDRFG 760 LGQAGRIPGS 770 VNAMRVLSTS 780 TDLEAAVADA 790 LLLGDSRSKK 800 KPVRRRYEPY 810 GMYSDDDANS 820 DASSVCSERS 830 YGSRNGGIPH 840 YLRQTEDVAE 850 VLNHCASSNW 860 SERKEGLLGL 870 QNLLKSQRTL 880 SRVELKRLCE 890 IFTRMFADPH 900 SKRVFSMFLE 910 TLVDFIIIHK 920 DDLQDWLFVL 930 LTQLLKKMGA 940 DLLGSVQAKV 950 QKALDVTRDS 960 FPFDQQFNIL 970 MRFIVDQTQT 980 PNLKVKVAIL 990 KYIESLARQM 1000 DPTDFVNSSE 1010 TRLAVSRIIT 1020 WTTEPKSSDV 1030 RKAAQIVLIS 1040 LFELNTPEFT 1050 MLLGALPKTF 1060 QDGATKLLHN 1070 HLKNSSNTSV 1080 GSPSNTIGRT 1090 PSRHTSSRTS 1100 PLTSPTNCSH 1110 GGLSPSMLDY 1120 DTENLNSEEI 1130 YSSLRGVTEA 1140 IEKFSFRSQE 1150 DLNEPIKRDG 1160 RKDCEIVPRD 1170 GGVASPATEG 1180 RGGSDVVAGG 1190 RTALDNKTSL 1200 LNTQPPRAFP 1210 GPRARDYSPY 1220 PYCDAISAYD 1230 KTALQEAVFD 1240 DDMEQLRDVP 1250 IDHSDLVADL 1260 LKELSNHNER 1270 VEERKGALLE 1280 LLKVTREDSL 1290 GVWEEHFKTI 1300 LLLLLETLGD 1310 KDHSIRALAL 1320 RVLREILRNQ 1330 PARFKNYAEL 1340 TIMKTLEAHK 1350 DSHKEVVRAA 1360 EEAASTLASS 1370 IHPEQCIKVL 1380 CPIIQTADYP 1390 INLAAIKMQT 1400 KVVERIAKES 1410 LLQLLADIIP 1420 GLLQGYDNTE 1430 SSVRKASVFC 1440 LVAIYSVIGE 1450 ELKPHLAQLT 1460 GSKMKLLNLY 1470 IKRAQTTNSN 1480 SSSSSDVSTH S

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.