Search Results
Overview
| Uniprot ID | F1RZ24 |
|---|---|
| Protein Name | H/ACA ribonucleoprotein complex subunit DKC1 |
| Gene Name | DKC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | ERATRLVKSQQSAGK |
| 152 | KSQQSAGKEYVGIVR |
| 454 | QLVAEAAKTPKRKRE |
| 62 | LLLKNFDKLNVRTTH |
| 81 | PCGSNPLKREIGDYI |
Function
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme
Protein Sequence
10
MACFVEVLIL
20
PKKHKKKKER
30
KSLPEEDVAE
40
IQHAEEFLIK
50
PESKVAQLDT
60
SQWPLLLKNF
70
DKLNVRTTHY
80
TPLPCGSNPL
90
KREIGDYIRT
100
GFINLDKPSN
110
PSSHEVVAWI
120
RRILRVEKTG
130
HSGTLDPKVT
140
GCLIVCIERA
150
TRLVKSQQSA
160
GKEYVGIVRL
170
HNAIEGGTQL
180
SRALETLTGA
190
LFQRPPLIAA
200
VKRQLRVRTV
210
YESKMIEFDP
220
ERRLGIFWVS
230
CEAGTYIRTL
240
CVHLGLLLGV
250
GGQMQELRRV
260
RSGVMSEKDH
270
MVTMHDVLDA
280
QWLYDNHKDE
290
SYLRRVVYPL
300
EKLLTSHKRL
310
VMKDSAVNAI
320
CYGAKIMLPG
330
VLRYEDGIEV
340
NQEIVVITTK
350
GEAICMAVAL
360
MTTAVISTCD
370
HGVVAKIKRV
380
IMERDTYPRK
390
WGLGPKASQK
400
RLMIKQGLLD
410
KHGKPTDSTP
420
AAWTQDYVDY
430
SDPAKKEAAA
440
KAVKAPPAVA
450
EAAKAPQLVA
460
EAAKTPKRKR
470
ESESDETSPA
480
AAQLPKKEKK
490
KKKDKKPKAA
500
PEGAAEPGDG
510
DSDTTKKKKK
520
KKKIKVEVVS
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031429 | box H/ACA snoRNP complex |
| Cellular Component | GO:0090661 | box H/ACA telomerase RNP complex |
| Cellular Component | GO:0015030 | Cajal body |
| Cellular Component | GO:0001650 | fibrillar center |
| Molecular Function | GO:0034513 | box H/ACA snoRNA binding |
| Molecular Function | GO:0009982 | pseudouridine synthase activity |
| Molecular Function | GO:0003720 | telomerase activity |
| Molecular Function | GO:0070034 | telomerase RNA binding |
| Biological Process | GO:0000495 | box H/ACA sno(s)RNA 3'-end processing |
| Biological Process | GO:0000455 | enzyme-directed rRNA pseudouridine synthesis |
| Biological Process | GO:1990481 | mRNA pseudouridine synthesis |
| Biological Process | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body |
| Biological Process | GO:0031118 | rRNA pseudouridine synthesis |
| Biological Process | GO:0031120 | snRNA pseudouridine synthesis |
| Biological Process | GO:0090669 | telomerase RNA stabilization |
| Biological Process | GO:0007004 | telomere maintenance via telomerase |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.