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Overview

Uniprot IDF1RZT2
Protein NamePrefoldin subunit 6
Gene NamePFDN6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
8 MAELIQKKLQGEVEK

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins

Protein Sequence

10 MAELIQKKLQ 20 GEVEKYQQLQ 30 KDLSKSMSGR 40 QKLEAQLTEN 50 NIVKEELALL 60 DGSNVVFKLL 70 GPVLVKQELG 80 EARATVGKRL 90 DYITAEIKRY 100 ESQLRELERQ 110 SEQQRETLAQ 120 LQQEFQRAQA AKAGAPGKA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016272 prefoldin complex
Molecular Function GO:0051087 protein-folding chaperone binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0006457 protein folding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.