Search Results
Overview
| Uniprot ID | F1S084 |
|---|---|
| Protein Name | Histone acetyltransferase type B catalytic subunit |
| Gene Name | HAT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | EKFLVEYKSAVEKKL |
Function
Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac)
Protein Sequence
10
FSGFGAMEKF
20
LVEYKSAVEK
30
KLAEYKCNTN
40
TAIELKLVRF
50
PEDLENDIRT
60
FFPYTHQLFG
70
DDETAFGYKG
80
LKILLYYIAG
90
SLSTMFRVEY
100
ASKVDENFDC
110
VEADDVEGKI
120
RQIIPPGFCT
130
NTSDFLSLLE
140
KEVDFKPFGT
150
LLHTYSVLSP
160
TGGENFTFQI
170
YKADMTCRGF
180
REYHERLQTF
190
LMWFIETASF
200
IDVDDERWHY
210
FLVFEKYNKD
220
GATLFATVGY
230
MTVYNYYVYP
240
DKTRPRVSQM
250
LILTPFQGQG
260
HGAQLLETVH
270
RYYIASPSVL
280
DITAEDPSKS
290
YVKLRDFVLV
300
KFCQGLPCFS
310
REKLMQGFNE
320
DMAVEAQQKF
330
KINKQHARRV
340
YEILRLLVTD
350
MSDAEQYRSY
360
RLDIKRRLIS
370
PYKKKQRDLA
380
KMRKCLRPEE
390
LTNQMNQIEI
400
SMQHEQLEES
410
FQELVEDYRR
VIERLAQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0042393 | histone binding |
| Molecular Function | GO:0010485 | histone H4 acetyltransferase activity |
| Molecular Function | GO:0043997 | histone H4K12 acetyltransferase activity |
| Molecular Function | GO:0140218 | histone methacryltransferase activity |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:0031509 | subtelomeric heterochromatin formation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.