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Overview

Uniprot IDF1S0P4
Protein NameDnaJ homolog subfamily C member 7
Gene NameDNAJC7
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
281 NNIKTNAKLYCNRGT
295 TVNSKLRKLDDAIED

Function

Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm

Protein Sequence

10 MAAAAECDVV 20 MAATGPELLD 30 DEEAKREAES 40 FKEQGNAYYA 50 KKDYNEAYNY 60 YTKAIDMCPK 70 NASYYGNRAA 80 TLMMLGRFRE 90 ALGDAQQSVR 100 LDDSFVRGHL 110 REGKCHLSLG 120 NAMAACRSFQ 130 RFKNANAVIE 140 YEKIAETDFE 150 KRDFRKVVFC 160 MDRALEFAPA 170 CHRFKILKAE 180 CLAMLGRYPE 190 AQSVASDILR 200 MDSTNADALY 210 VRGLCLYYED 220 CIEKAVQFFV 230 QALRMAPDHE 240 KACIACRNAK 250 ALKAKKEDGN 260 KAFKEGNYKL 270 AYELYTEALG 280 IDPNNIKTNA 290 KLYCNRGTVN 300 SKLRKLDDAI 310 EDCTHAVKLD 320 DTYIKAYLRR 330 AQCYMDTEQY 340 EEAVRDYEKV 350 YQTEKTKEHK 360 QLLKNAQLEL 370 KKSKRKDYYK 380 ILGVDKNASE 390 DEIKKAYRKR 400 ALMHHPDRHS 410 GASAEVQKEE 420 EKKFKEVGEA 430 FTILSDPKKK 440 TRYDSGQDLD 450 EEGMNMGGES GAAWGSPG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005634 nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.