Search Results
Overview
| Uniprot ID | F1S108 |
|---|---|
| Protein Name | CDGSH iron-sulfur domain-containing protein 2 |
| Gene Name | CISD2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | YCRCWRSKTFPACDG |
| 116 | ACDGSHNKHNELTGD |
| 131 | NVGPLILKKKEV*** |
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy
Protein Sequence
10
MVLECVARIV
20
KVQLPAYLKR
30
LPIPESITGF
40
ARLTVSEWLR
50
LLPFLGVLAL
60
LGYLAVRPFL
70
PKKKQQKDSL
80
INLKIQKENP
90
KVVNEINIED
100
LCLTKAAYCR
110
CWRSKTFPAC
120
DGSHNKHNEL
130
TGDNVGPLIL
KKKEV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0097038 | perinuclear endoplasmic reticulum |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0000422 | autophagy of mitochondrion |
| Biological Process | GO:0010506 | regulation of autophagy |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.