Overview
| Uniprot ID | F1S1B9 |
|---|
| Protein Name | Dehydrogenase/reductase SDR family member 11 |
|---|
| Gene Name | DHRS11 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 107 |
ALVQHGLKVVGCART |
Function
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones
Protein Sequence
10
MWPIAEGRRV
20
EPGAEASGSG
30
SSSRRSYDGT
40
RLAAGSALVT
50
RERPGPSDVG
60
RSSAIQVPSS
70
PSEVGGRLGT
80
LTWAGMERWR
90
GRLALVTGAS
100
GGIGAAVARA
110
LVQHGLKVVG
120
CARTVGNIEE
130
LAAECKSAGY
140
PGTLIPYKCD
150
LSNEEDILSM
160
FSAIRSQHSG
170
VDICINNAGL
180
ARPDSLLSGS
190
TSGWKDMFNV
200
NVLALSICTR
210
EAYQSMRERK
220
VDDGHIININ
230
SMSGHRVVPQ
240
SVAHFYSATK
250
YAVTALTEGL
260
RQELREAQTH
270
IRATCISPGV
280
VETQFAFKLH
290
DKNPEKAAAA
300
YEQMKCLKAE
310
DVAEAVIYVL
320
STPPHVQVSL
330
TLAVHPPGGA
340
QPSPDEESRE
350
AFGGGGSILA
360
SSSLVSSADR
370
GHPDEAHGAG
380
DLVSREELFL
390
PSPPLTARHS
PLGFRC
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0000253 |
3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.