Overview
| Uniprot ID | F1S1E1 |
|---|
| Protein Name | DDB1- and CUL4-associated factor 13 |
|---|
| Gene Name | DCAF13 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 48 |
VRALNATKLERVFAK |
| 97 |
VRIWNLTKRKCIRTI |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition
Protein Sequence
10
MKVKMLSRNP
20
DNYVRETKLD
30
LQRVPRNYDP
40
ALHPFEPREY
50
VRALNATKLE
60
RVFAKPFLAS
70
LDGHRDGVNC
80
LAKHPKSLAT
90
VLSGACDGEV
100
RIWNLTKRKC
110
IRTIQAHEGF
120
VRGICTRFCG
130
TSFFTVGDDK
140
TVKQWKMDGP
150
SYGEDEEPLH
160
TILGKTVYTG
170
IDHHWKEAIF
180
ATCGQQVDIW
190
DEQRTNPICS
200
MTWGFDSISS
210
VKFNPIETFL
220
LGSCASDRNI
230
VLYDMRQATP
240
LKKVILDMRT
250
NTIGWNPMEA
260
FIFTAANEDY
270
NLYTFDMRAL
280
DTPIMVHMDH
290
VSAVLDVDYS
300
PTGKEFVSAS
310
FDKSIRIFPV
320
DKSRSREVYH
330
TKRMQHVICV
340
KWTSDSKYIM
350
CGSDEMNIRL
360
WKANASEKLG
370
VLTSREKAAT
380
DYNQRLKEKF
390
QHHPHIKRIS
400
RHRHLPKSIY
410
SQIQEQRIMK
420
EARRRKELNR
430
IKHSKPGSVR
440
IVSEKKKHIV
AVVK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0080008 |
Cul4-RING E3 ubiquitin ligase complex |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0030331 |
nuclear estrogen receptor binding |
| Molecular Function |
GO:1990756 |
ubiquitin-like ligase-substrate adaptor activity |
| Biological Process |
GO:0046697 |
decidualization |
| Biological Process |
GO:0044725 |
epigenetic programming in the zygotic pronuclei |
| Biological Process |
GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Biological Process |
GO:0001555 |
oocyte growth |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0007056 |
spindle assembly involved in female meiosis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.