Search Results
Overview
| Uniprot ID | F1S227 |
|---|---|
| Protein Name | Peptidyl-tRNA hydrolase 2, mitochondrial |
| Gene Name | PTRH2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 115 | WEYCGQPKVVVKAPD |
Function
Peptidyl-tRNA hydrolase which releases tRNAs from the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1
Protein Sequence
10
MISMPLVMEY
20
LANPGALSFA
30
AGVACGMCLG
40
WGLRVRFGMI
50
PKSSVSETDT
60
DTETEASILG
70
ESGEYKMILV
80
VRNDLKMGKG
90
KVAAQCSHAA
100
VSAYKQIQRR
110
NPELLQQWEY
120
CGQPKVVVKA
130
PDEETLVELL
140
THAKMLGLTV
150
SLIQDAGRTQ
160
IAPGSRTVLG
170
IGPGPVDLID
KVTGHLKLY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0004045 | peptidyl-tRNA hydrolase activity |
| Biological Process | GO:2000811 | negative regulation of anoikis |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:2000210 | positive regulation of anoikis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.