Search Results
Overview
| Uniprot ID | F1S232 |
|---|---|
| Protein Name | 4-trimethylaminobutyraldehyde dehydrogenase |
| Gene Name | ALDH9A1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | NLAVQDAKAAFKIWS |
| 351 | EMSAKGIKPVTLELG |
| 400 | GTRVFVQKEILDKFT |
| 412 | KFTEEVVKQTQRIKI |
| 418 | VKQTQRIKIGDPLLE |
| 446 | ERILGFVKVAKEQGA |
Function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines
Protein Sequence
10
MKVPKSLPNS
20
ALEGRALARR
30
PGNSSPSPAT
40
PLSPLRELCP
50
RAACPSHGPA
60
PSPFRLSVPP
70
PKPCPSPRPL
80
NWCPRLPRVF
90
LRAGLAVLSP
100
LLRTLRPAPV
110
AAMSTGTFIV
120
SQPLNYRGGA
130
RVDPVDASGT
140
EKAFEPATGR
150
VIATFTCSGE
160
KEVNLAVQDA
170
KAAFKIWSQK
180
SGMERCRILL
190
EAARIIRERK
200
EEIATMETIN
210
NGKSIFEARL
220
DVDISWQCLE
230
YYAGLAGSMA
240
GEHIQLPGGS
250
FGYTRREPLG
260
VCVGIGAWNY
270
PFQIACWKSA
280
PALACGNAMI
290
FKPSPFTPLS
300
VLLLAEIYTE
310
AGVPPGLFNV
320
VQGGATTGQL
330
LCQHRDVAKI
340
SFTGSVPTGS
350
KIMEMSAKGI
360
KPVTLELGGK
370
SPLIIFSDCD
380
MGNAVKGALM
390
ANFLTQGEVC
400
CNGTRVFVQK
410
EILDKFTEEV
420
VKQTQRIKIG
430
DPLLEDTRMG
440
PLINRPHLER
450
ILGFVKVAKE
460
QGAKVLCGGD
470
LYVPEDPKLK
480
EGYYMRPCVL
490
TNCRDDMTCV
500
KEEIFGPVMS
510
ILSFDTEAEV
520
VERANDTTFG
530
LAAGVFTRDI
540
QRAHRVVAEL
550
QAGMCFINNY
560
NVSPVELPFG
570
GYKKSGFGRE
580
NGRVTIEYYS
590
QLKTVCVEMG
DVESVF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0047105 | 4-trimethylammoniobutyraldehyde dehydrogenase activity |
| Molecular Function | GO:0019145 | aminobutyraldehyde dehydrogenase (NAD+) activity |
| Molecular Function | GO:0018467 | formaldehyde dehydrogenase (NAD+) activity |
| Biological Process | GO:0045329 | carnitine biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.