Search Results

Overview

Uniprot IDF1S2J4
Protein NameEnhancer of mRNA-decapping protein 4
Gene NameEDC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1093 ISKLLKSKNLTDAIA
120 ARGSNKVKIQPVAKY
360 LFCDNHKKQDPEVPF

Function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)

Protein Sequence

10 MASSCASIDI 20 EDATQHLRDI 30 LKLDRPAGGP 40 SAESQRPSNA 50 YNGDLNGLLV 60 PDPLCSGDGT 70 SANKPGLRAM 80 PPINLQEKQV 90 ICLSGDDSST 100 CIGILAKEVE 110 IVASSDSSIS 120 SKARGSNKVK 130 IQPVAKYDWE 140 QKYYYGNLIA 150 VSNSFLAYAI 160 RAANNGSAMV 170 RVISVSTSER 180 TLLKGFTGSV 190 ADLAFAHVNS 200 PQLACLDEAG 210 NLFVWRLALV 220 NGKIQEEILV 230 HIRQPEGTPL 240 NHFRRIIWCP 250 FIPEESEDCC 260 EEGSPTVALL 270 HEDRAEVWDL 280 DMLRSNHNTW 290 PVDVSQIKQG 300 FIVVKGHSTC 310 LSEGALSPDG 320 TVLATASHDG 330 FVKFWQIYIE 340 GQDEPRCLHE 350 WKPHDGRPLS 360 CLLFCDNHKK 370 QDPEVPFWRF 380 LITGADQNRE 390 LKMWCTVSWT 400 CLQTIRFSPD 410 IFSSVSVPPS 420 LKVCLDLSAE 430 YLILSDVQRK 440 VLYVMELLQN 450 QEEGCACFSS 460 ISEFLLTHPV 470 LSFGIQVVSR 480 CRLRHTEVLP 490 AEEETDSLGA 500 DGTHGAGAME 510 SAAGVLIKLF 520 CVHTKALQDV 530 QIRFQPQLNP 540 DVVAPLPTHP 550 AHEDFAFGES 560 RSELGSEGLG 570 STTHGSQPDL 580 RRIVELPAPA 590 NFLSLSNETK 600 PKLMTPDAFM 610 TPSASLQQIA 620 ASPSSSSSSS 630 SSSSSSSSSS 640 LTAVSAMSST 650 SAVDPSLPRP 660 PEELTLSPKL 670 QLDGGLTISS 680 SSSLQASPRG 690 LLPGLLPGPA 700 DKLTPKGPGQ 710 VLTAASALSL 720 ELQEMEPLGL 730 PQASPTRTRS 740 PDVISSASTA 750 LSQDIPEIAS 760 EALSRGFGSS 770 APEGLEPDSM 780 ASAASALHLL 790 SPRPRPGPEL 800 GPQLSLDGGP 810 GDGDRHSAPS 820 LLEAALTQET 830 TAPDSQVWPT 840 APDITRETCS 850 SLAESPRNGL 860 QEKHKSLAFH 870 RPPYHLLQQH 880 DSQDASAEQS 890 DHDDEVASLA 900 SAAGGFGTKV 910 PTPRLPAKDW 920 KTKGSPRASP 930 KLKRKGKKDD 940 GDSSMGSRLT 950 EHQVAETPED 960 WPALIWQQQR 970 ELAQLRHSQE 980 ELLQRLCTQL 990 EGLQSTVMGH 1000 VERALESRHE 1010 QEQRRLERAL 1020 AEGQQRGGQL 1030 QEQLTQQLSQ 1040 ALSSAVAGRL 1050 ERSIRDEIKK 1060 TVPPCVSRSL 1070 EPVAGQLSNS 1080 VATKLTAVEG 1090 SMKESISKLL 1100 KSKNLTDAIA 1110 RAAADTLQGP 1120 MQAAYREAFQ 1130 SVVLPAFEKS 1140 CQAMFQQIND 1150 SFRLGTQEYL 1160 QQLESHMKSR 1170 KAREQEAREP 1180 VLAQLRGLVS 1190 TLQGATEQMA 1200 ATVSSSVRAE 1210 VQHQLHVAVG 1220 SLQESILAQV 1230 QRIVKGEVSV 1240 ALKEQQAAVT 1250 SSIMQAMRSA 1260 AGTPVPAAHL 1270 DCQAQQAHIL 1280 QLLQQGHLNQ 1290 AFQQALTAAD 1300 LNLVLYVCET 1310 VDPGQVFGQP 1320 PCPLSQPVLL 1330 SLIQQLASDL 1340 GTRTDLKLSY 1350 LEEAVMHLDH 1360 SDPITRDHMG 1370 SVMAQVRQKL 1380 FQFLQAEPHN 1390 SLGKAARRLS 1400 LMLHGLMTPS LP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000932 P-body
Biological Process GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.