Overview
| Uniprot ID | F1S320 |
|---|
| Protein Name | Cyclin-dependent kinase 14 |
|---|
| Gene Name | CDK14 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 148 |
NGKLVALKVIRLQEE |
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport
Protein Sequence
10
MYCTEKLSDS
20
FSRIALKKDD
30
TTFDEICVTK
40
MSTRNCPGMD
50
SMIKPLDTIP
60
EDKKVRVQRT
70
QSTFDPFEKP
80
ANQVKRVHSE
90
NNACINFKTS
100
SAGKESPKVR
110
RHSSPSSPTS
120
PKFGKADSYE
130
KLEKLGEGSY
140
ATVYKGKSKV
150
NGKLVALKVI
160
RLQEEEGTPF
170
TAIREASLLK
180
GLKHANIVLL
190
HDIIHTKETL
200
TLVFEYVHTD
210
LCQYMDKHPG
220
GLHPENVKLF
230
LFQLLRGLSY
240
IHQRYILHRD
250
LKPQNLLISD
260
TGELKLADFG
270
LARAKSVPSH
280
TYSNEVVTLW
290
YRPPDVLLGS
300
TEYSTCLDMW
310
GVGCIFVEMI
320
QGVAAFPGMK
330
DIQDQLERIF
340
LVLGTPNEDT
350
WPGVHSLPHF
360
KPERFTLYSS
370
KNLRQAWNKL
380
SYVNHAEDLA
390
SKLLQCSPKN
400
RLSAQAALSH
410
EYFSDLPPRL
420
WELTDMSSIF
430
TVPNVRLQPE
440
AGESTRAFGK
450
NNSYGKSLSN
SKH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.