Overview
| Uniprot ID | F1S3C7 |
|---|
| Protein Name | AP-1 complex subunit gamma |
|---|
| Gene Name | AP1G1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 122 |
GEVEKLLKTSNSYLR |
| 131 |
SNSYLRKKAALCAVH |
| 337 |
KDLDVSIKRRAMELS |
| 764 |
IKVLNPQKQQLRMRI |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes
Protein Sequence
10
MIQKECAAIR
20
SSFREEDNTY
30
RCRNVAKLLY
40
MHMLGYPAHF
50
GQLECLKLIA
60
SQKFTDKRIG
70
YLGAMLLLDE
80
RQDVHLLMTN
90
CIKNDLNHST
100
QYVQGLALCT
110
LGCMGSSEMC
120
RDLAGEVEKL
130
LKTSNSYLRK
140
KAALCAVHVI
150
RKVPELMEMF
160
LPATKNLLNE
170
KNHGVLHTSV
180
VLLTEMCERS
190
PDMLAHFRKL
200
VPQLVRILKN
210
LIMSGYSPEH
220
DVSGISDPFL
230
QVRILRLLRI
240
LGRNDDDSSE
250
AMNDILAQVA
260
TNTETSKNVG
270
NAILYETVLT
280
IMDIKSESGL
290
RVLAINILGR
300
FLLNNDKNIR
310
YVALTSLLKT
320
VQTDHNAVQR
330
HRSTIVDCLK
340
DLDVSIKRRA
350
MELSFALVNG
360
NNIRGMMKEL
370
LYFLDSCEPE
380
FKADCASGIF
390
LAAEKYAPSK
400
RWHIDTIMRV
410
LTTAGSYVRD
420
DAVPNLIQLI
430
TNSVEMHAYT
440
VQRLYKAILG
450
DYSQQPLVQV
460
AAWCIGEYGD
470
LLVSGQCEEE
480
EPIQVTEDEV
490
LDILESVLIS
500
NMSTSVTRGY
510
ALTAIMKLST
520
RFTCTVNRIK
530
KVVSIYGSSI
540
DVELQQRAVE
550
YNALFKKYDH
560
MRSALLERMP
570
VMEKVTTNGP
580
TEIVQTNGET
590
EPAPLETKPP
600
PSGPQPTSQA
610
NDLLDLLGGN
620
DITPVIPTAP
630
TSKPASAGGE
640
LLDLLGDINL
650
TGAPSAAPAP
660
ASVPQISQPP
670
FLLDGLSSQP
680
LFNDIATGIP
690
SITAYSKNGL
700
KIEFTFERSN
710
TNPSVTVITI
720
QASNSTELDM
730
TDFVFQAAVP
740
KTFQLQLLSP
750
SSSIVPAFNT
760
GTITQVIKVL
770
NPQKQQLRMR
780
IKLTYNHKGS
790
AMQDLAEVNN
FPPQSWQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030121 |
AP-1 adaptor complex |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0035615 |
clathrin adaptor activity |
| Molecular Function |
GO:0030742 |
GTP-dependent protein binding |
| Molecular Function |
GO:0019894 |
kinesin binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0035646 |
endosome to melanosome transport |
| Biological Process |
GO:0090160 |
Golgi to lysosome transport |
| Biological Process |
GO:0006896 |
Golgi to vacuole transport |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0043323 |
positive regulation of natural killer cell degranulation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.