Overview
| Uniprot ID | F1S3J9 |
|---|
| Protein Name | Intercellular adhesion molecule 1 |
|---|
| Gene Name | ICAM1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 432 |
ARGNPTPKLICRREG |
Function
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1
Protein Sequence
10
MAPGATHPGQ
20
LALLALLLPL
30
LGALLPGLGG
40
AEISMWPLNT
50
IIPKGGSMKV
60
NCSVACDGNI
70
TSFGLETHWH
80
KTEVDHRDKW
90
KIFELSNVEN
100
DGTLLCHAVC
110
QGNQTQVQGN
120
LTVYWFPEYV
130
KLANLSWQRE
140
GQHFNLSCQV
150
SGGAPRTNLS
160
AVLFRGEEEL
170
FRQSVGMEEP
180
ANVTFRMLAS
190
RKDHGANFSC
200
RTELNLQPQG
210
LELFWNSSAP
220
LKLQTYVLPA
230
THPHLATPEL
240
VEVGTPVSVN
250
CSLDGLFPAS
260
EATVHLARGD
270
HRPPLTITHN
280
GDSLLAKTWI
290
NGTEKEQGTQ
300
YLVCEIMLAD
310
EKVVTKKNVT
320
FYSFPPPNLT
330
LSEPEVSEGT
340
TVSIECQAHG
350
EAVVTLNEVP
360
AETPSQRAQL
370
KLNVSAEDHG
380
RSFSCSAALT
390
VAGHVLYKNQ
400
TQVLSVLYGP
410
RLDERDCPGN
420
WTWPEGSHQT
430
LTCQARGNPT
440
PKLICRREGD
450
GALLPTGDLG
460
PVKREITGTY
470
QCQATSSRGV
480
ATRVVVVNVI
490
HNQNNMVIII
500
PVAAVAILGS
510
VGVAAYIYNY
520
QRKIQKYELQ
530
KAQENAAMKL
STPASPP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009897 |
external side of plasma membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005178 |
integrin binding |
| Molecular Function |
GO:0048018 |
receptor ligand activity |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0033631 |
cell-cell adhesion mediated by integrin |
| Biological Process |
GO:1904646 |
cellular response to amyloid-beta |
| Biological Process |
GO:0061028 |
establishment of endothelial barrier |
| Biological Process |
GO:0061756 |
leukocyte adhesion to vascular endothelial cell |
| Biological Process |
GO:0050900 |
leukocyte migration |
| Biological Process |
GO:0022614 |
membrane to membrane docking |
| Biological Process |
GO:2000352 |
negative regulation of endothelial cell apoptotic process |
| Biological Process |
GO:1902042 |
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process |
GO:0002693 |
positive regulation of cellular extravasation |
| Biological Process |
GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0046813 |
receptor-mediated virion attachment to host cell |
| Biological Process |
GO:0002291 |
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.