Search Results
Overview
| Uniprot ID | F1S3P6 |
|---|---|
| Protein Name | CCN family member 2 |
| Gene Name | CCN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 277 | LSGCTSVKTYRAKFC |
| 282 | SVKTYRAKFCGVCTD |
| 62 | GCCRVCAKQLGELCT |
| 78 | RDPCDPHKGLFCDFG |
| 91 | FGSPANRKIGVCTAK |
| 98 | KIGVCTAKDGAPCVF |
Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis
Protein Sequence
10
MSATGLSPVR
20
CAFVLLLALC
30
SRPASGQDCS
40
GQCQCAAGKA
50
PRCPAGVSLV
60
LDGCGCCRVC
70
AKQLGELCTE
80
RDPCDPHKGL
90
FCDFGSPANR
100
KIGVCTAKDG
110
APCVFGGTVY
120
RSGESFQSSC
130
KYQCTCLDGA
140
VGCVPLCSMD
150
VRLPSPDCPF
160
PRRVKLPGKC
170
CEEWVCDEPK
180
DHTVVGPALA
190
AYRLEDTFGP
200
DPTMMRANCL
210
VQTTEWSACS
220
KTCGMGISTR
230
VTNDNAFCRL
240
EKQSRLCMVR
250
PCEADLEENI
260
KKGKKCIRTP
270
KISKPVKFEL
280
SGCTSVKTYR
290
AKFCGVCTDG
300
RCCTPHRTTT
310
LPVEFKCPDG
320
EVMKKSMMFI
330
KTCACHYNCP
340
GDNDIFESLY
YRKMYGDMA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0005178 | integrin binding |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0071897 | DNA biosynthetic process |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0045597 | positive regulation of cell differentiation |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:0051496 | positive regulation of stress fiber assembly |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.