Search Results
Overview
| Uniprot ID | F1S3U9 |
|---|---|
| Protein Name | Peroxiredoxin-1 |
| Gene Name | PRDX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 16 | GHRAPHFKATAVMPD |
| 168 | QAFQFTDKHGEVCPA |
| 178 | EVCPAGWKPGSDTIK |
| 185 | KPGSDTIKPDVQKSK |
| 190 | TIKPDVQKSKEYFSK |
| 192 | KPDVQKSKEYFSKQK |
| 197 | KSKEYFSKQK***** |
| 27 | VMPDGQFKDISLSDY |
| 35 | DISLSDYKGKYVVFF |
| 68 | ERAEEFKKLNCQVIG |
| 7 | *MSSGNAKIGHRAPH |
| 92 | LAWINTPKKQGGLGP |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation
Protein Sequence
10
MSSGNAKIGH
20
RAPHFKATAV
30
MPDGQFKDIS
40
LSDYKGKYVV
50
FFFYPLDFTF
60
VCPTEIIAFS
70
ERAEEFKKLN
80
CQVIGASVDS
90
HFCHLAWINT
100
PKKQGGLGPM
110
NIPLISDPKR
120
TIAQDYGVLK
130
ADEGISFRGL
140
FIIDDKGILR
150
QITINDLPVG
160
RSVDETLRLV
170
QAFQFTDKHG
180
EVCPAGWKPG
190
SDTIKPDVQK
SKEYFSKQK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0045321 | leukocyte activation |
| Biological Process | GO:0019430 | removal of superoxide radicals |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.