Search Results
Overview
| Uniprot ID | F1S418 |
|---|---|
| Protein Name | Thioredoxin-dependent peroxide reductase, mitochondrial |
| Gene Name | PRDX3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 246 | TPDSPTIKPHPTDSK |
| 96 | ELSLDDYKGKYLVLF |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength
Protein Sequence
10
MAAAAAAAAG
20
RLLRASVIRH
30
VSAVPWGISA
40
SAALRPAPSR
50
RTCLTSVLWS
60
GSSQAKFAFS
70
TSSSHHSPAV
80
TQHAPYFKGT
90
AVVNGEFKEL
100
SLDDYKGKYL
110
VLFFYPLDFT
120
FVCPTEIIAF
130
SDKANEFHDV
140
NCEVVAVSVD
150
SHFSHLAWIN
160
TPRKNGGLGH
170
MNIALLSDLT
180
KQISRDYGVL
190
LEGPGLALRG
200
LFIIDPNGVI
210
KHLSVNDLPV
220
GRSVEETLRL
230
VKAFQFVETH
240
GEVCPANWTP
250
DSPTIKPHPT
260
DSKEYFEKVH
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0051881 | regulation of mitochondrial membrane potential |
| Biological Process | GO:0042542 | response to hydrogen peroxide |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.