Overview
| Uniprot ID | F1S4V8 |
|---|
| Protein Name | Copine-1 |
|---|
| Gene Name | CPNE1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 258 |
QQKKKSYKNSGIVRV |
Function
Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL
Protein Sequence
10
MEMAHCVTLV
20
QLSISCDHLT
30
DKDIGSKSDP
40
LCVLLQDVGG
50
GTWAELGRTE
60
RVRNCSSPEF
70
SKTLQLEYHF
80
ETVQKLRFGI
90
YDIDNKTPEL
100
GDDDFLGGAE
110
CSLGQIVSSQ
120
ILTLPLMLKP
130
GKPAGRGTIT
140
VSAQELKDSR
150
VVTMEVEARN
160
LDKKDFLGKS
170
DPFLEFFRQG
180
DGKWHLAYRS
190
EVIKNNLNPT
200
WKRFSVPFQH
210
FCGGDPSTPI
220
QVRCSDYDSD
230
GSHDLIGTFH
240
TTLAQLQAVP
250
AEFECIHPEK
260
QQKKKSYKNS
270
GIVRVKICQV
280
ETEYSFLDYV
290
MGGCQINFTV
300
GVDFTGSNGD
310
PSSPDSLHYL
320
SPTGVNEYLT
330
ALWSVGSVVQ
340
DYDSDKLFPA
350
FGFGAQVPPD
360
WQVSHEFALN
370
FNPSNPYCAG
380
IQGIVDAYRQ
390
ALPQVRLYGP
400
TNFAPIINHV
410
ARFAAQAAHQ
420
KSASQYFVLL
430
LLTDGAVTDV
440
EATREAVVRA
450
SYLPMSVIIV
460
GVGGADFEAM
470
EQLDADGGPL
480
HTRSGEAARW
490
VLDFAPREAL
500
AQTVLAEVPT
510
QLVSYFKAQG
520
WAPFKPLPPP
530
TKGPAQAPQA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0005544 |
calcium-dependent phospholipid binding |
| Molecular Function |
GO:0004175 |
endopeptidase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0051059 |
NF-kappaB binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:1901223 |
negative regulation of non-canonical NF-kappaB signal transduction |
| Biological Process |
GO:1990138 |
neuron projection extension |
| Biological Process |
GO:0045666 |
positive regulation of neuron differentiation |
| Biological Process |
GO:0051897 |
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process |
GO:1903265 |
positive regulation of tumor necrosis factor-mediated signaling pathway |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0043122 |
regulation of canonical NF-kappaB signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.