Overview
| Uniprot ID | F1S564 |
|---|
| Protein Name | RNA 3'-terminal phosphate cyclase |
|---|
| Gene Name | RTCA |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 191 |
TDRGSVTKIYGRAFV |
Function
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury
Protein Sequence
10
MAGPRVEVDG
20
GIMEGGGQIL
30
RVSTALSCLL
40
GLPLRVQKIR
50
AGRSTPGLRP
60
QHLSGLEMVR
70
DLCDGQLEGA
80
EIGSTEIMFT
90
PEKIKGGTHT
100
ADTKTAGSVC
110
LLMQVSMPCV
120
LFAASPSELR
130
LKGGTNAEMA
140
PQIDYTAMVF
150
KPIVEKFGFT
160
FNCDIKMRGY
170
YPKGGGEVIV
180
RMSPVKQLNP
190
INLTDRGSVT
200
KIYGRAFVAG
210
VLPFKVAKDM
220
AAAAVRCIRK
230
EIRDLYVNIQ
240
PVQEPKDQAF
250
GNGSGIIIIA
260
ETSTGCLFAG
270
SSLGKRGVNA
280
DKVGIEAAEV
290
LLANLRHGGA
300
VDEYLQDQLI
310
IFMALASGIS
320
RIKTGPVTLH
330
TQTAIHFAEQ
340
LAKAKFTVKK
350
SEDEEDASKD
360
TYIIECQGIG
MTNPNL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0003963 |
RNA-3'-phosphate cyclase activity |
| Biological Process |
GO:0006396 |
RNA processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.