Search Results

Overview

Uniprot ID	F1S596
Protein Name	Glucosidase 2 subunit beta
Gene Name	PRKCSH
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
141	REGFRLKKILIEDWK
148	KILIEDWKKAREEKQ
157	AREEKQKKLIEIQAG
195	EAKDQHRKLWEEQQA
385	AAQEARNKFEEAERS
440	VYRLCPFKHVSQKPK
447	KHVSQKPKLGGSPTS

Function

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia

Protein Sequence

10 MLLFLLLLPM 20 CWAVEVKRPR 30 GVSLTNHHFY 40 DESKPFTCLD 50 GSASIPFDQV 60 NDDYCDCKDG 70 SDEPGTAACP 80 NGSFHCSNTG 90 YKPLYISSRW 100 VNDGVCDCCD 110 GTDEYNSGIV 120 CENTCKEKGR 130 KERETLQQMA 140 EVTREGFRLK 150 KILIEDWKKA 160 REEKQKKLIE 170 IQAGKKSLED 180 QVEMLRAVKE 190 EAEKPEKEAK 200 DQHRKLWEEQ 210 QAASKAQREQ 220 ELAANAFQEL 230 DDDMDGVVSV 240 AELQTHPELD 250 TDGDGALSEG 260 EAQTLLGGDS 270 QTDAASFYDR 280 IWAAIRDKYR 290 SEVPPTDVPS 300 PSAPDLTEPK 310 EEQPPVPSPP 320 TEEEDEDQDE 330 EEEETEEEEE 340 EEEEEDSQVQ 350 AEQPKEAPPP 360 LVTPQTVSPT 370 EEDKMPPYDE 380 QTQAFIDAAQ 390 EARNKFEEAE 400 RSLRDMEESI 410 RNLEQEISFD 420 FGPDGEFAYL 430 YSQCYELTTN 440 EYVYRLCPFK 450 HVSQKPKLGG 460 SPTSLGTWGS 470 WAGPDHDKFS 480 AMKYEQGTGC 490 WQGPNRSTTV 500 RLLCGRETVV 510 TSTTEPSRCE 520 YLMELTTPAA 530 CPEPPPEPPT EGDHDEL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0017177	glucosidase II complex
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0001889	liver development
Biological Process	GO:0006491	N-glycan processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.