Search Results

Overview

Uniprot IDF1S6G2
Protein NameNardilysin
Gene NameNRDC
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
921 PGAHHLCKVRALNKG

Function

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH)

Protein Sequence

10 MLRRVTVAAV 20 SATGRKLWCE 30 AGRELAALWR 40 VEARGRCEDS 50 AAARPFPTLT 60 MPGRNKAKST 70 CSCPDLQPNG 80 QDLGESGRVA 90 RLGADESEEE 100 GRRVPVSNAG 110 DPEIVKSPSD 120 PKQYRYIKLR 130 NGLQALLISD 140 LSNMEGKMGD 150 ATDDEEEEEE 160 EEEDDNDDDD 170 DDDDDEDSGA 180 EIEDDDEEGF 190 DDEDEFDDDD 200 DDEHDDDDDL 210 DTEDNELEEL 220 EERAEARKKT 230 TEKQSAAALC 240 VGVGSFADPD 250 DLPGLAHFLE 260 HMVFMGSLKY 270 PDENGFDAFL 280 KKHGGSDNAS 290 TDCERTVFQF 300 DVQRKYFKEA 310 LDRWAQFFIH 320 PLMIRDAIDR 330 EVEAVDSEYQ 340 LARPSDANRK 350 EMLFGSLARP 360 GHPMGKFFWG 370 NAETLKHEPK 380 RNNIDTHARL 390 REFWMRFYSA 400 HYMTLVVQSK 410 ETLDTLEKWV 420 TEIFSQIPNN 430 GLPKPNFGHL 440 TDPFDTPAFN 450 KLYRVVPIRK 460 IHALTITWAL 470 PPQQQHYRSK 480 PLHYISWLVG 490 HEGKGSILSY 500 LRKKCWALAL 510 FGGNGETGFE 520 QNSTYSVFSI 530 SITLTDEGYE 540 HFYEVAHTVF 550 QYLKMLQKLG 560 PEKRIFEEIQ 570 KIEDNEFHYQ 580 EQTDPVEYVE 590 NMCENMQLYP 600 LQDFLTGDQL 610 LFEYKPEVIA 620 EALNQLVPQK 630 ANLVLLSGAN 640 EGKCDLKEKW 650 FGTQYSMEDI 660 ENSWAELWKS 670 NFELNPDLHL 680 PAENKYIATD 690 FMLKAFDCPE 700 TEYPVKIVNT 710 PQGCLWYKKD 720 NKFKIPKAYI 730 RFHLISPLIQ 740 KSAANVVLFD 750 IFVNILTHNL 760 AEPAYEADVA 770 QLEYKLVAGE 780 HGLIIRVKGF 790 NHKLPLLFQL 800 IIDYLAEFTS 810 TPAVFTMITE 820 QLKKTYFNIL 830 IKPETLAKDV 840 RLLILEYARW 850 SMIDKYRALM 860 DGLSLESLLS 870 FVKEFKAQLF 880 VEGLVQGNVT 890 STESTDFLKY 900 VVDKLNFMPL 910 EQEMPVQFRV 920 VELPGAHHLC 930 KVRALNKGDA 940 NSEVTVYYQS 950 GARSLKEYTL 960 MELLVMHMEE 970 PCFDFLRTKQ 980 TLGYHVYPTC 990 RNTSGILGFS 1000 VTVGTQATKY 1010 NSEVVDKKIE 1020 EFLSSFEEKI 1030 ENLTEDAFNT 1040 QVTALIKLKE 1050 CEDTHLGEEV 1060 DRNWNEVVTQ 1070 QYLFDRLAHE 1080 IEALKSFSKS 1090 DLVSWFKAHR 1100 GPGSKMLSVH 1110 VVGFGKHELE 1120 EDGIPSSEDS 1130 NSSCEVMQLT 1140 YLPASPLLAD 1150 STIPITDIRA 1160 FTSTLNLLPY HKIVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004222 metalloendopeptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.