Search Results
Overview
| Uniprot ID | F1S6R5 |
|---|---|
| Protein Name | WD repeat-containing protein 18 |
| Gene Name | WDR18 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 253 | TWPGQREKSFQPEQD |
Function
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May play a role during development
Protein Sequence
10
MAAPMEVAVC
20
TDSAAQLWSC
30
VVWELHSGAN
40
LLTYRGGQAG
50
PRGLALLNGE
60
YLLAAQLGKN
70
YISAWELQRK
80
DQLQQKIMCP
90
GPVTCLTTSP
100
NGLYVLAGIA
110
ESIYLWEVST
120
GNLLVILSRH
130
YQDVSCLQFT
140
GDSSHFLSGG
150
KDCLVLAWSL
160
CSVLQADPSR
170
TPAPRHVWSR
180
HTLPITDLHC
190
GFGGPLARVA
200
TASLDQTVKL
210
WEVSSGELLL
220
SVLFDVGIMA
230
VTMDLAEHHM
240
FCGGSDGSIF
250
QVDLCTWPGQ
260
REKSFQPEQD
270
SGKVFRGHRN
280
QVTCLSVSTD
290
GSVLLSGSHD
300
ETVRLWDVQS
310
QQCLRTVTLK
320
GPVTNATIML
330
APVSMLSSDF
340
RPSLPLPHFN
350
KHLLGAEHGD
360
ELHHGGLTLR
370
LGLHQQGSEP
380
SYLERAEQLH
390
SVMCSTMEKN
400
VLGGQDQLRI
410
RVTELEDEVR
420
NLRKINRDLF
430
DFSTHIITRP
AK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0120293 | dynein axonemal particle |
| Cellular Component | GO:0005656 | nuclear pre-replicative complex |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0120330 | rixosome complex |
| Biological Process | GO:0006261 | DNA-templated DNA replication |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.