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Overview

Uniprot IDF1S710
Protein NameCalcyclin-binding protein
Gene NameCACYBP
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
145 ISVEGSSKKVKTDTV
173 DYLTQVEKECKEKEK
21 EVKVLLEKATRKRVR
214 DMKRTINKAWVESRE
87 YGWDQSDKFVKIYIT

Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1)

Protein Sequence

10 MASALEELQK 20 DLEEVKVLLE 30 KATRKRVRDT 40 LTTEKSKIET 50 EIKNKMQQKS 60 QRKAELLENE 70 KPAAVVAPIT 80 TGYTVKISNY 90 GWDQSDKFVK 100 IYITLTGVHQ 110 VPTENVQVHF 120 TERSFDLLVK 130 NLNGKNYSMI 140 VNNLLKPISV 150 EGSSKKVKTD 160 TVLILCRKKA 170 ENTRWDYLTQ 180 VEKECKEKEK 190 PSYDTETDPS 200 EGLMNVLKKI 210 YEDGDDDMKR 220 TINKAWVESR 230 EKQAKGDTEF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030877 beta-catenin destruction complex
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0019005 SCF ubiquitin ligase complex
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0044548 S100 protein binding
Molecular Function GO:0015631 tubulin binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0007507 heart development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.